摘要
目的分析同型半胱氨酸(homocysteine,Hcy)、D-二聚体(D-dimer,D-D)水平与低年龄段急性心肌梗死(acute myocardial infarction,AMI)发病风险的相关性。方法选取2021年1月—2022年6月本院收治的低年龄段AMI患者为观察组(n=120例),另选择在本院体检健康人群为对照组(n=120例),对比分析2组血清Hcy、超敏C-反应蛋白(high sensitivity C-reactive protein,hs-CRP)、D-D水平。依据CTA检查结果将患者分为冠状动脉狭窄轻度组(观察1组,n=48例)、中度组(观察2组,n=46例)、重度组(观察3组,n=26例),对比3组患者基础资料和化验指标,分析低年龄段AMI患者发病风险的影响因素及血清Hcy、D-D水平与低年龄段AMI患者发病的相关性。结果观察组血清Hcy、hs-CRP、D-D水平均高于对照组(P<0.05)。观察2组、观察3组患者纤维原蛋白(fibrinogen,Fib)、脱脂转化酶(degreasing invertase,LPa)、尿酸(uric acid,UA)、Hcy、D-D、hs-CRP、血钙水平高于观察1组(P<0.05)。以Fib、LPa、UA、Hcy、D-D、hs-CRP、血钙为自变量进行logistic回归分析,Hcy、D-D为低年龄段AMI患者发病的独立危险因素(P<0.05)。低年龄段AMI患者发病风险与血清Hcy水平、血清D-D水平成正相关(r值分别为0.817、0.927,P<0.05)。结论血清Hcy、D-D水平为低年龄段AMI患者发病的独立危险因素,检测其水平可作为评估和预测低年龄段AMI发病的重要指标。
Objective This paper aims to analyze the relationship between homocysteine(Hcy)and D-dimer(D-D)levels and the risk of acute myocardial infarction(AMI)in young age.Methods Low-age AMI patients admitted to our hospital from January 2021 to June 2022 were selected as the observation group(n=120),and healthy people in our hospital were selected as the control group(n=120).Serum levels of Hcy,high sensitivity C-reactive protein(hs-CRP)and D-D were compared and analyzed between the two groups.According to CTA examination results,patients were divided into mild coronary artery stenosis group(observation 1 group,n=48),moderate coronary artery stenosis group(observation 2 group,n=46),and severe coronary artery stenosis group(observation 3 group,n=26).The basic data and laboratory indicators of patients in the three groups were compared to analyze the influencing factors of AMI risk and the correlation between serum Hcy,D-D levels and the incidence of AMI in patients of low age.Results The serum levels of Hcy,hs-CRP and D-D in observation group were higher than those in control group(P<0.05).The levels of fibrinogen(Fib),degreasing invertase(LPa),uric acid(UA),Hcy,D-D,hs-CRP and serum calcium in group 2 and group 3 were higher than those in group 1(P<0.05).Logistic regression analysis was conducted with Fib,LPa,UA,Hcy,D-D,HS-CRP and blood calcium as independent vari⁃ables,and Hcy and D-D were independent risk factors of AMI in young age patients(P<0.05).There was a positive correla⁃tion between the risk of AMI and the serum level of Hcy and D-D(r=0.817,r=0.927,P<0.05).Conclusion Serum levels of Hcy and D-D are independent risk factors for the incidence of AMI in patients of low age.Detection of serum Hcy and D-D levels can be used as an important indicator to evaluate and predict the incidence of AMI in patients of low age.
作者
吴冬京
林初希
黄象维
吕攀
WU Dong-jing;LIN Chu-xi;HUANG Xiang-wei;LV Pan(不详;Department of Clinical Laboratory,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325027,China)
出处
《中国卫生检验杂志》
CAS
2023年第13期1617-1620,共4页
Chinese Journal of Health Laboratory Technology
