摘要
目的 探讨青年急性心肌梗死（AMI）患者冠脉病变与血浆脂蛋白相关磷脂酶A2（Lp—PLA2）水平的关系。方法选择31例青年AMI患者为研究对象（AMI组），28例冠脉造影正常的青年人为对照组（NC组），比较两组临床资料、冠脉病变特点，使用酶联免疫吸附法（EusA）检测两组患者血浆Lp—PLA2水平。结果青年AMI组吸烟、高胆固醇血症、冠心病家族史比例显著高于Nc组（P＜0．01）；AMI组血浆Lp—PLA2水平较Nc组显著增高（P〈0．01），且血浆Lp—PLA2水平与冠脉Gemini积分呈正相关（r=0．726，P〈0．01）。结论血浆LD—PLA2水平可能反映青年AMI患者冠脉病变程度。
Objective To discuss the relationship between young patients with acute myocardial in- farction （AMI）and lipoprotein-associated phospholipase A2（Lp-PLA2 ）. Methods 31 young patients with AMI, who were confirmed by coronary angiography, were enrolled as AMI group,at the same time,28 cases of healthy young as control group.We collected their clinical data and results of coronary angiography. The plasma level of Lp-PLA2 were measured by ELISA. Results Compared to control group, AMI group had higher smoking, family history,and hypercholester（P〈0.01）. The plasma level of Lp-PLA2 in the patients of the AMI group increased more significantly than the control group （P〈0.01）. There were relation between the plasma level of Lp-PLA2 and coronary Gensini score （r =0.726, P〈0.01）. Conclusion The plasma level of LpPLA2 may reflect the degree of coronary artery pathogenic changes in young patients with AMI.
出处
《中国心血管病研究》
CAS
2013年第9期715-718,共4页
Chinese Journal of Cardiovascular Research
基金
内蒙古自治区人民医院院内基金项目（项目编号：20110927）
关键词
脂蛋白相关磷脂酶A2
急性心肌梗死
Lipoprotein-associated phospholipase A2
Acute myocardial infarction
