摘要
目的探讨银屑病患者血小板、抗凝血功能检测的临床意义。方法选择2020年2月—2022年2月潍坊市皮肤病防治所收治的银屑病患者55例作为观察组研究对象,选择同时间潍坊市皮肤病防治所接收的健康体检者55例作为对照组。两组采血进行血小板参数平均血小板体积(meam platelet volume,MPV)、血小板分布宽度(platelet distribution width,PDW)、血浆β-血小板球蛋白(plasmaβ-thromboglobulin,β-TG)、血小板表面α颗粒膜蛋白140(granule membrane protein-140,GMP-140)、血小板第4因子(platelet factor 4,PF4)、血栓素B2(thromboxane B2,TXB2)及抗凝血功能参数抗凝血酶-Ⅲ抗原(antithrombin-Ⅲ:antigen,AT-Ⅲ:Ag)、蛋白C抗原(protein C:antigen,PC:Ag)、抗凝血酶-Ⅲ活性(antithrombin-Ⅲ:activity,AT-Ⅲ:A)、蛋白C活性(protein C:activity,PC:A)检验,比较两组血小板参数及抗凝血功能检测水平,比较观察组不同分型患者的血小板参数及抗凝血功能检测水平。结果观察组MPV、PDW、β-TG、GMP-140、PF4、TXB2检测水平显著高于对照组,AT-Ⅲ:Ag、PC:Ag、AT-Ⅲ:A、PC:A检测水平显著低于对照组(P<0.05)。观察组进行期患者β-TG、GMP-140、PF4、TXB2检测水平显著高于静止期患者,AT-Ⅲ:Ag、PC:Ag、AT-Ⅲ:A、PC:A检测水平显著低于静止期患者(P<0.05)。观察组进行期患者与静止期患者MPV、PDW检测水平比较,差异无统计学意义(P>0.05)。结论银屑病患者抗凝血功能降低,血小板功能进一步激活、释放,导致血小板参数明显增高,抗凝血功能参数明显降低,并会受到病程发展影响,即可依据血小板、抗凝血功能参数评估银屑病的发生及进展,研究价值较高。
Objective To investigate the clinical significance of platelet and anticoagulant function detection in patients with psoria sis.Methods A total of 55 patients with psoriasis admitted to Weifang Dermatology Prevention and Treatment Institute from February 2020 to February 2022 were selected as subjects of the observation group,and 55 healthy people admitted to Weifang Dermatology Prevent ion and Treatment Ins titute at the same time were selected as the control group.Blood of the two groups was collected and meam platelet volume(MPV)was measured.Platelet distribution width(PDW),plasmaβ-thromboglobulin(β-TG),platelet surfaceαgranule protein-140(GMP-140),platelet factor 4(PF4),thromboxane B2(thromboxane B2,TXB2)and Antithrombin-Ⅲ:antigen,AT-Ⅲ:Ag),protein C:antigen,PC:Ag,antithrombin-Ⅲactivity(antithrombin-Ⅲ:antigen,AT-Ⅲ:Ag)activity,AT-Ⅲ:A),protein C activity(protein C:activity,PC:A)were test,the two groups of platelet parameters and anticoagulation function detection levels were compared,the observation group of different types of patients with platelet parameters and anticoagulation function detection levels were compared.Results The levels of MPV,PDW,β-TG,GMP-140,PF4 and TXB2 in observation group were significantly higher than those in control group,while the levels of AT-Ⅲ:Ag,PC:Ag,AT-Ⅲ:A and PC:A were significantly lower than those in control group(P<0.05).The levels ofβ-TG,GMP-140,PF4 and TXB2 in the observation group were significantly higher than those in the stationary phase,while the levels of AT-Ⅲ:Ag,PC:Ag,AT-Ⅲ:A and PC:A were significantly lower than those in the stationary phase(P<0.05).There was no statistical significance in MPV and PDW detection between patients in marching stage and patients in stationary stage in observation group(P>0.05).Conclusion The anticoagulant function of patients with psoriasis is decreased,platelet function is further activated and released,resulting in significantly increased platelet parameters,significantly reduced anticoagulant function paramete
作者
刘志香
乔嘉伟
张洁
LIU Zhixiang;QIAO Jiawei;ZHANG Jie(Department of Clinical Laboratory,Weifang Dermatology Prevention and Treatment Institute,Weifang Shandong 261061,China)
出处
《中国卫生标准管理》
2023年第13期115-118,共4页
China Health Standard Management
