摘要
自闭症谱系障碍(autism spectrum disorder,ASD)是一种神经发育障碍性疾病,因其发病率持续上升,引起了全球的关注。研究发现,肠道菌群(gut microbiota)与ASD之间有一定的关联性,体内动态平衡的肠道菌群可以保证人体正常的生命活动,但当其失去稳态时可能会通过改变神经递质、代谢物、免疫系统、HPA轴和肠道通透性等影响ASD的发生发展。益生菌、益生元以及粪菌移植等肠道菌群干预对于治疗ASD有一定效果。中医药也可通过干预肠道菌群达到一定的治疗ASD的目的。本文旨在通过总结肠道菌群紊乱影响ASD的机制,为ASD的研究和治疗提供参考。
Autism spectrum disorder(ASD)is a kind of neurodevelopmental disorder that has attracted global attention because of its continued rise in incidence.There is a correlation between gut microbiota and ASD.Homeostasis of gut microbiota ensures normal life activities and may affect the occurrence and development of ASD through changing neurotransmitters,metabolites,the immune system,HPA axis,and intestinal permeability by losing its homeostasis.Gut microbiota treatment method,such as probiotics,prebiotics,and fecal microbiota transplantation,have a treatment effects on ASD.Additionally,traditional Chinese medicine may exert a certain treatment effect on ASD by through gut microbiota.The purpose of this review was to summarize the mechanism of gut microbiota disturbance affecting ASD as well as related research method and models to provide reference for the research and treatment of ASD.
作者
董丽仙
尹爱武
李灿委
范孟然
巫秀美
杨自忠
张成桂
高鹏飞
DONG Lixian;YIN Aiwu;LI Canwei;FAN Mengran;WU Xiumei;YANG Zizhong;ZHANG Chenggui;GAO Pengfei(College of Pharmacy,Dali University,Dali 671000,China;Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,Dali University,Dali 671000;National Joint Engineering Research Center for the Development of Medicinal Special Insects,Dali University,Dali 671000;Xiangtan Medicine and Health Vocational College,Xiangtan 411104;College of Public Health,Dali University,Dali 671000)
出处
《中国比较医学杂志》
CAS
北大核心
2023年第6期95-101,共7页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金资助项目(81260676,82160798,81960712)
中国国家留学基金(201708535007)
云南省重大科技专项计划—生物资源数字化开发应用(202002AA100007)。
关键词
肠道菌群
自闭症谱系障碍
机制
gut microbiota
autism spectrum disorder
mechanism
