摘要
目的:观察清热利咽汤联合西药治疗反流性咽喉炎的临床疗效。方法:采用随机数字表法将98例反流性咽喉炎患者分为对照组及治疗组各49例。对照组给予常规西药治疗,治疗组给予常规西药联合清热利咽汤治疗。比较2组临床疗效及治疗前后血清分泌型免疫球蛋白A(SIgA)、胃泌素(GAS)、降钙素原(PCT)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、肿瘤坏死因子-α(TNF-α)、核转录因子-κB(NF-κB)、活性肠肽(VIP)、胃动素(MTL)及唾液表皮生长因子(EGF)含量;比较2组治疗前后食管下括约肌压力(LESP)、食管上括约肌压力(UESP)、食管远端收缩积分平均值(DCI)、收缩前沿速度(CFV);比较2组治疗前后反流症状指数量表(RSI)、反流体征评分(RFS)、咽喉反流患者生活质量量表(LPR-HRQL)评分、中医证候评分。结果:治疗后,治疗组总有效率95.92%,高于对照组85.71%(P<0.05)。治疗后,2组PGⅠ、EGF、GAS、MTL、SIgA含量及LESP、DCI、UESP均较治疗前升高(P<0.05),且治疗组治疗后上述指标高于对照组(P<0.05)。治疗后,2组PGⅡ、VIP、TNF-α、PCT、NF-κB含量及CFV、RSI、LPR-HRQL、RFS、中医证候评分均较治疗前降低(P<0.05),且治疗组治疗后上述指标低于对照组(P<0.05)。结论:清热利咽汤联合西药治疗反流性咽喉炎疗效确切,能有效缓解患者反流症状、体征,改善胃肠功能、炎症反应及食管动力学,提高患者生活质量。
Objective:To observe the clinical effect of Qingre Liyan Decoction combined with western medicine for reflux laryngitis.Methods:A total of 98 cases of patients with reflux laryngitis were divided into the control group and the treatment group according to the random number table method,with 49 cases in each group.The control group was treated with routine western medicine,and the treatment group was treated with routine western medicine combined with Qingre Liyan Decoction.The contents of secretory immunoglobulin A(SIgA),gastrin(GAS),procalcitonin(PCT),pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),tumor necrosis factor-α(TNF-α),nuclear factor-κB(NF-κB),vasoactive intestinal peptide(VIP),and motilin(MTL)in serum and salivary epidermal growth factors(EGF)before and after treatment as well as the clinical effects were compared between the two groups;lower esophageal sphincter pressure(LESP),upper esophageal sphincter pressure(UESP),mean value of esophageal distal contraction integral(DCI)and contractile front velocity(CFV)were compared before and after treatment between the two groups;the evaluation of Reflux Symptom Index Scale(RSI),Reflux Findings Score(RFS),Laryngopharyngeal Reflux-Health-related Quality of Life Score(LPR-HRQL)and traditional Chinese medicine(TCM)syndrome scores were compared before and after treatment between the two groups.Results:After treatment,the total effective rate was 95.92%in the treatment group,higher than that of 85.71%in the control group(P<0.05).After treatment,the contents of PGⅠ,EGF,GAS,MTL and SIgA as well as LESP,DCI and UESP in the two groups were increased when compared with those before treatment(P<0.05),and the above indexes in the treatment group were higher than those in the control group(P<0.05).After treatment,the contents of PG-Ⅱ,VIP,TNF-α,PCT,NF-κB,CFV,RSI,LPRHRQL,RFS and TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the above indexes in the treatment group were lower than those in the control group(P<0
作者
付志刚
王振鹏
张刚强
FU Zhigang;WANG Zhenpeng;ZHANG Gangqiang
出处
《新中医》
CAS
2023年第11期140-145,共6页
New Chinese Medicine
基金
河南省医学科技攻关计划联合共建项目(LHGJ20191100)。
关键词
反流性咽喉炎
清热利咽汤
胃肠激素
炎症反应
食管动力学
生活质量
Reflux laryngitis
Qingre Liyan Decoction
Gastrointestinal hormone
Inflammatory response
Esophageal dynamics
Quality of life
