摘要
目的:分析妊娠中期孕妇血清学筛查结果,探讨不同筛查风险与母胎不良结局的关联。方法:选取2019—2021年在合肥市新站区接受孕中期血清学筛查的孕妇,评估胎儿患21-三体综合征、18-三体综合征和开放性神经管缺陷的风险,分别计算3种疾病高风险和低风险的发生率,并随访获得妊娠结局,分析不同风险组胎儿不良妊娠结局的发生率。结果:在接受妊娠中期血清学筛查的11 821名孕妇中,检出21-三体综合征高风险孕妇560人,检出率为4.74%;检出18-三体综合征高风险孕妇28人,检出率为0.24%;检出开放性神经管缺陷高风险孕妇53人,检出率为0.45%。实际随访获得妊娠结局的孕妇共11 606人,其中,高风险组孕妇自然流产、死胎、出生缺陷和低出生体重的发生率分别为1.12%、1.60%、4.17%和3.37%,显著高于低风险组(0.32%、0.30%、1.16%和2.12%)。高风险组孕妇靶向疾病、其他染色体疾病、其他出生缺陷的发生率分别为1.12%、1.12%和1.44%,均高于低风险组(0.05%、0.02%和0.65%)。结论:妊娠中期血清学筛查高风险与自然流产、死胎、出生缺陷、出生低体重等母胎不良妊娠结局具有一定的相关性,对出生缺陷的预测具有指导意义。
OBJECTIVE To analyze the results of serological screening in the second trimester,and to explore the association be-tween different screening risks for adverse maternal and fetal outcomes.METHODS Pregnant women who underwent second-trimes-ter serological screening in Xinzhan district of Hefei from 2019 to 2021 were selected.The incidences of high--risk and low--risk of 21-trisomy sy ndrome,18-trisomy syndrome and open neural tube defects were counted,and the pregnancy outcomes were followed up to analyze the incidence of adverse matermal--fetal outcomes in different risk groups.RESULTS Among the 11821 pregnant wom-en undergoing serological screening in the second trimester,560 pregnant women with high risk of 21-3 syndrome,with a detection rate of 4.74%;28 pregnant women with high risk of 18-3 syndrome with a detection rate of 0.24%;53 pregnant women with high risk of open neural tube defects,with a detection rate of 0.45%.A total of 11606 pregnant women with pregnancy outcomes,sponta-neous abortion,sillbirth,birth defects and low birth weight were 1.12%,1.60%,4.17%and 3.37%,respectively,signifcantly higher than the low--risk group(0.32%,0.30%,1.16%,2.12%).The incidence of targeted disease,other chromosomal disease,and other birth defects were 1.12%,1.12%,and 1.44%,respectively,all higher than the low risk group(0.05%,0.02%,0.65).CONCLUSION The high risk of serological screening in the second trimester is correlated with adverse matermnal-fetal pregnancy outcomes,such as spontaneous abortion,sillbirth,birth defects and low birth weight,and is instructive for the prediction of birth defects.
作者
黄晓曼
谢钱茹
邵子瑜
HUANG Xiao-man;XIE Qian-ru;SHAO Zi-yu(Hefei Women and Children Health Care Center,Hefei,Anhui,230031,China)
出处
《中国初级卫生保健》
2023年第6期39-41,45,共4页
Chinese Primary Health Care
关键词
孕妇
血清学筛查
唐氏筛查
妊娠结局
优生优育
pregnant women
serological screening
down screening
pregnancy outcomes
prenatal and postnatal care
