摘要
目的:对58789名中孕期血清学产前筛查结果呈不同风险孕妇的不良妊娠结局进行分析,探讨中孕期血清学筛查结果与不良妊娠结局的相关性。方法:回顾性分析2022年在合肥市妇女儿童保健中心接受中孕期血清学产前筛查的58789名单胎孕妇的筛查结果,并对其妊娠结局、羊水穿刺和超声检查结果进行随访,比较21-三体综合征和18-三体综合征不同风险组孕妇不良妊娠结局发生率。结果:21-三体综合征、18-三体综合征高风险组、临界风险组、低风险组孕妇其他染色体异常、超声结构异常、自然流产发生率比较,差异有统计学意义(21-三体:χ^(2)值分别为388.117、9.285、10.279,18-三体:χ^(2)值分别为39.908、24.536、67.047,P值均<0.05),其中21-三体综合征、18-三体综合征各风险组孕妇其他染色体异常、超声结构异常、自然流产发生率均为高风险组最高。18-三体综合征高风险组、临界风险组其他染色体异常发生率高于21-三体综合征临界风险组,差异有统计学意义(χ^(2)值分别为5.472、7.126,P值均<0.05);18-三体综合征高风险组超声结构异常发生率高于21-三体综合征高风险组和临界风险组,差异有统计学意义(χ^(2)值分别为6.094、8.042,P值均<0.05)。结论:中孕期母血清学三联筛查除了能够筛查出目标疾病,对不良妊娠结局也有一定的预测作用,联合产前诊断和超声检测可以降低出生缺陷的发生率。
OBJECTIVE To analyze the adverse pregnancy outcomes of 58789 pregnant women with different risks of prenatal screening during mid pregnancy,and explore the correlation between mid pregnancy serological screening results and adverse pregnancy outcomes.METHODS Retrospective analysis of prenatal serological screening results in 58789 pregnant women,comparing the incidence of adverse pregnancy outcomes between different risk groups of trisomy 21 and trisomy 18.RESULTS The overall comparison of the incidence of other chromosomal abnormalities,ultrasound structural abnormalities,and spontaneous abortion between different risk groups of trisomy 21 and trisomy 18 showed statistically significant differences(21trisomy:χ^(2)=388.117,9.285,10.279;18 trisomy:χ^(2)=39.908,24.536,67.047,P<0.05).Pairwise comparison showed that the incidence of other chromosomal abnormalities and ultrasound structural abnormalities in the high-risk groups of trisomy 21 and trisomy 18 was higher than that in the low-risk group,and the differences were statistically significant.The incidence of other chromosomal abnormalities in the high-risk and critical risk groups of trisomy 18 is higher than that in the critical risk group of trisomy 21,and the difference is statistically significant(χ^(2)=5.472,7.126,P<0.05),the incidence of ultrasound structural abnormalities in the high-risk group of trisomy 18 was higher than that in the high-risk group of trisomy 21(χ^(2)=6.094,P<0.05)and critical risk group(χ^(2)=8.042,P<0.05).CONCLUSION The triple screening of maternal serology during mid pregnancy not only identifies the target disease,but also has a certain predictive effect on adverse pregnancy outcomes.Combining prenatal diagnosis and ultrasound testing can reduce the occurrence of birth defects.
作者
周玲
孙瑜
李辉
杭春梅
邵子瑜
Zhou Ling;Sun Yu;Li Hui;Hang Chunmei;Shao Ziyu(Maternal&Child Health and Family Planning Service Center,Hefei,Anhui,230601,China)
出处
《中国初级卫生保健》
2024年第5期46-49,共4页
Chinese Primary Health Care
基金
合肥市卫生健康委2021年应用医学研究项目(Hwk2021yb020)。
