摘要
目的:探讨高频重复经颅磁刺激对女性精神分裂症患者症状的改善效果。方法:收集2021年4月—2022年4月江西康宁医院精神科收治的女性精神分裂症患者54例,采取随机数字表法进行分组,两组各27例。对照组口服奥氮平,初始剂量为10 mg/d,逐渐增加剂量至10~20 mg/d;观察组在此基础上给予高频重复经颅磁刺激治疗,每次20 min,每日1次,每周治疗5 d,休息2 d;两组均治疗4周。比较两组治疗效果、治疗期间不良反应发生情况、治疗前后阳性和阴性症状量表(PANSS)评分、蒙特利尔认知评估量表(MoCA)评分以及精神分裂症生活质量量表(SQLS)评分的变化情况。结果:观察组治疗总有效率为88.89%(24/27),高于对照组的62.96%(17/27,P<0.05)。观察组治疗4周后PANSS总评分、阳性症状评分、阴性症状评分、一般精神病理评分均低于对照组(P<0.05),MoCA评分则高于对照组(P<0.05),SQLS评分低于对照组(P<0.05)。两组不良反应总发生率均为18.52%(P>0.05)。结论:对女性精神分裂症患者而言,采取高频重复经颅磁刺激治疗,有利于患者症状的改善、认知功能和生活质量的提高,疗效显著,安全性良好,值得临床推荐。
Objective:To explore the effect of high-frequency repetitive transcranial magnetic stimulation on the improvement of symptoms in female patients with schizophrenia.Methods:A total of 54 female schizophrenic patients admitted to the Department of Psychiatry of Kangning Hospital,Jiangxi from April 2021 to April 2022 were collected and divided into two groups with 27 cases in each group with random number table method.The control group took the olanzapine,the initial dose was 10 mg/d,and gradually increased to 10-20 mg/d;on this basis,the observation group was treated with high-frequency repetitive transcranial magnetic stimulation,20 minutes each time,once a day,5 days a week,and 2 days a rest;both groups were treated for 4 weeks.The treatment effect,adverse reactions during treatment,positive and negative symptom scale(PANSS)scores before and after treatment,Montreal cognitive assessment scale(MoCA)scores and schizophrenic quality of life scale(SQLS)scores were compared between the two groups.Results:The total effective rate of treatment was 88.89%(24/27)in the observation group,which was higher than 62.96%(17/27)in the control group(P<0.05).After 4 weeks of treatment,the total PANSS score,positive symptom score,negative symptom score and general psychopathological score in the observation group were lower than those in the control group(P<0.05),the MoCA score in the observation group was higher than that in the control group(P<0.05),and the SQLS score in the observation group was lower than that in the control group(P<0.05).The total incidence of adverse reactions in both groups was 18.52%(P>0.05).Conclusion:For female schizophrenic patients,high-frequency repetitive transcranial magnetic stimulation treatment is beneficial to the improvement of symptoms,cognitive function and quality of life of patients,and has significant curative effect and good safety,which is worthy of clinical recommendation.
作者
叶平
YE Ping(Department of Psychiatry of Kangning Hospital,Zhangshu City,Jiangxi Province 331211,China)
出处
《上海医药》
CAS
2023年第14期22-25,共4页
Shanghai Medical & Pharmaceutical Journal
关键词
精神分裂症
女性
高频重复经颅磁刺激
认知功能
生活质量
schizophrenia
female sex
high frequency repetitive transcranial magnetic stimulation
cognitive function
quality of life
