摘要
目的探讨术前D-二聚体/纤维蛋白原比值对年轻乳腺癌患者保乳术后复发的影响。方法采用回顾性研究,收集2019年11月至2021年11月于濮阳市人民医院接受保乳术的132例年轻乳腺癌患者的临床资料,依据术后复发情况分为复发组(n=14)与未复发组(n=118),由研究者统计两组患者一般资料并进行比较,同时收集并比较两组患者术前凝血功能指标(凝血酶时间、凝血酶原时间、部分活化凝血酶原时间、纤维蛋白原、D-二聚体、D-二聚体/纤维蛋白原比值),采用Cox回归分析术前D-二聚体/纤维蛋白原比值对患者复发的影响,并绘制受试者工作特征(ROC)曲线评估术前D-二聚体/纤维蛋白原比值对年轻乳腺癌患者保乳术后复发的预测价值。结果两组年龄、体重指数、初潮年龄、肿瘤部位、乳腺影像报告和数据系统(BI-RADS)分级、手术时间、住院时间、凝血酶时间、凝血酶原时间、部分活化凝血酶原时间对比,差异无统计学意义(P>0.05);复发组肿瘤分期Ⅱ期占比、肿块大小、D-二聚体、纤维蛋白原、D-二聚体/纤维蛋白原比值均高于未复发组,差异有统计学意义(P<0.05);经Cox回归分析结果显示,纤维蛋白原、D-二聚体/纤维蛋白原比值为年轻乳腺癌患者保乳术后复发的危险因素(HR>1,P<0.05);绘制ROC曲线,结果显示,纤维蛋白原、D-二聚体/纤维蛋白原比值预测复发的曲线下面积(AUC)均>0.7,且D-二聚体/纤维蛋白原比值预测价值更高。结论术前D-二聚体/纤维蛋白原比值对年轻乳腺癌患者保乳术后复发具有一定影响,且对于术后复发的发生具有一定预测价值。
Objective To investigate the effect of preoperative D-dimer/fibrinogen ratio on the recurrence of young breast cancer patients after breast conserving surgery.Methods A retrospective study was conducted to collect the clinical data of 132 young breast cancer patients who received breast conserving surgery in Puyang People’s Hospital from November 2019 to November 2021.According to the postoperative recurrence,the patients were divided into recurrent group(n=14)and non recurrent group(n=118).The general data of the two groups of patients were collected and compared by the investigators.At the same time,the preoperative coagulation function indexes(thrombin time,prothrombin time,partial activated prothrombin time,fibrinogen,D-dimer,D-dimer/fibrinogen ratio)were collected and compared between the two groups.Cox regression analysis was used to analyze the effect of preoperative D-dimer/fibrinogen ratio on the recurrence of patients,and the receiver operating characteristic(ROC)curve was drawn to evaluate the predictive value of preoperative D-dimer/fibrinogen ratio on the recurrence of young breast cancer patients after breast conserving surgery.Results There was no significant difference in age,body mass index,menarche age,tumor location,breast imaging reporting and data system(BI-RADS)classification,operation time,hospitalization time,thrombin time,prothrombin time and partial activated prothrombin time between the two groups(P>0.05).The proportion of tumor stageⅡ,tumor size,D-dimer,fibrinogen and D-dimer/fibrinogen ratio in the recurrent group were higher than those in the non recurrent group,with a statistically significant difference(P<0.05).Cox regression analysis showed that fibrinogen and D-dimer/fibrinogen ratio were risk factors for recurrence of young breast cancer patients after breast conserving surgery(HR>1,P<0.05).The ROC curve was plotted,and the results showed that the area under the curve(AUC)of fibrinogen and D-dimer/fibrinogen ratio for predicting recurrence were all greater than 0.7,and the D
作者
刘大宁
刘湛
李世杰
LIU Daning;LIU Zhan;LI Shijie(Department of Clinical Laboratory,Puyang People’s Hospital,Puyang 457000,China)
出处
《河南医学研究》
CAS
2023年第14期2597-2600,共4页
Henan Medical Research
基金
河南省科技攻关计划项目(172102210025)。
关键词
乳腺癌
保乳术
复发
D-二聚体
纤维蛋白原
breast cancer
breast conserving surgery
recurrence
D-dimer
fibrinogen
