摘要
目的评价银杏二萜内酯葡胺注射液(DGMI)联合依达拉奉右崁对急性缺血性脑卒中(AIS)的治疗效果。方法回顾性分析我院2021年3月—2022年6月收治的86例AIS患者,根据治疗方法不同,分为单药组和联合组,每组43例,2组均予以DGMI治疗,联合组加用依达拉奉右崁醇。对比2组的治疗效果。结果治疗后,联合组美国国立卫生研究院卒中量表(NIHSS)评分低于单药组(P<0.05),简易智能精神状态检查量表(MMSE)和Barthel指数(BI)得分高于单药组(P<0.05);联合组治疗后脑血流动力学指标(Qmin和Vmin)高于单药组(P<0.05),而全血还原黏度、血浆黏度和血小板聚集指数低于单药组(P<0.05);联合组治疗后血清丙二醛(MDA)、超敏C-反应蛋白(hsCRP)和白细胞介素-6(IL-6)低于单药组(P<0.05),而超氧化物歧化酶(SOD)高于单药组(P<0.05);联合组治疗总有效率88.37%,高于单药组的67.44%(P<0.05),且2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论DGMI联合依达拉奉右崁醇可有效提高AIS患者的神经功能、认知功能及日常生活能力,降低血液高凝状态,改善脑部血流,缓解机体氧化应激及炎症反应,且不良反应发生率较低,安全性良好。
Objective To evaluate the clinical efficacy of diterpene ginkgolides meglumine injection(DGMI)combined with edaravone dextracanthol in the treatment of acute ischemic stroke(AIS).Methods A total of 86 patients with AIS admitted to our hospital from March 2021 to June 2022 were divided into single drug group and combination group according to different treatment methods,with 43 patients in each group.Both groups were treated with DGMI,and the combination group was added with edaravone dextracanthol.The therapeutic effect,neurological function and adverse reactions of the two groups were compared.Results After treatment,compared with the single drug group,the NIH Stroke Scale(NIHSS)score of the combination group was significantly lower(P<0.05),and the Mini-Mental State Examination(MMSE)and Barthel index(BI)scores were significantly higher(P<0.05).After treatment,the cerebral hemodynamic indexes(Qmin and Vmin)in the combination group were significantly higher(P<0.05),while the whole blood reducing viscosity,plasma viscosity and platelet aggregation index were significantly lower(P<0.05).After treatment,compared with the single drug group,the serum malondialdehyde(MDA),high sensitive C-reactive protein(hsCRP)and interleukin-6(IL-6)levels in the combination group were significantly lower(P<0.05),while the level of superoxide dismutase(SOD)was significantly higher(P<0.05).The total effective rate of the combination group was 88.37%,which was significantly higher than 67.44%of the single drug group(P<0.05).The incidence of adverse reaction between two groups was not significant(P>0.05).Conclusions DGMI combined with edaravone dextracanthol can effectively improve the neurological function,cognitive function and daily living ability of patients with AIS,reduce blood hypercoagulability,improve cerebral blood flow,alleviate oxidative stress and inflammatory reaction,improve the therapeutic effect,without increasing the incidence of adverse reactions,which has good safety.
作者
任亚丽
买雷
REN Yali;MAI Lei(Department of Pharmacy,Luoyang Third People’s Hospital,Luoyang 471000,China;Department of Neurology,Luoyang Third People’s Hospital,Luoyang 471000,China)
出处
《广州医药》
2023年第6期68-73,共6页
Guangzhou Medical Journal
