摘要
目的探讨定坤丹在氯米芬促排卵周期中对薄型子宫内膜的治疗效果,为临床提供依据。方法募集2018至2022年期间就诊于首都医科大学附属北京妇产医院内分泌科的患者,在氯米芬促排卵周期中呈现薄型子宫内膜共127例,在保证组间基本特征匹配原则上利用计算机软件产生的随机数随机分配到对照组和试验组。其中试验组64例给予定坤丹+戊酸雌二醇干预,对照组63例单纯给予戊酸雌二醇干预。治疗3个周期后对比两组患者之间人绒毛膜促性腺激素(human chorionic gonadotropin,HCG)日子宫内膜厚度、分型、黄体期孕激素浓度、3个周期排卵率、累计临床妊娠率的差异。结果3个月后试验组和对照组患者HCG日平均子宫内膜厚度分别为(8.30±1.068)mm和(7.43±1.051)mm,A型内膜占比分别为52.0%和32.7%。黄体期孕酮浓度分别为(11.00±1.508)ng/mL和(10.23±2.278)ng/mL,3个周期内排卵率分别为88.4%和79.7%,累计临床妊娠率分别为40.6%和22.2%,试验组均显著高于对照组(P<0.05)。结论定坤丹可以协同雌激素治疗氯米芬促排卵周期中子宫内膜过薄的问题,改善内膜型态、提高氯米芬排卵率、黄体功能以及临床妊娠率。
Objective To explore the effective of Dingkundan on thin endometrium in the clomiphene induced ovulation cycle,and provide basis for clinical practice.Methods A total of 127 patients who visited department of gynecological endocrinology,with thin endometrium in clomiphene induced ovulation cycle were recruited.Patients were randomly assigned to the control group and the experimental group based on the principle of ensuring basic feature comparable between groups.A total of 64 patients in experimental group were treated with Dingkun Pill+estrodiol,while a total of 63 patients in control group were treated with estrodiol.The endometrial thickness and type on human chorionic gonadotropin(hCG)day,progesterone level,ovulation rate,and clinical pregnancy rate between the two groups were compared.Results The average endometrial thickness on hCG day in the experimental group was significantly higher than that in the control group[(8.30±1.068)mm vs(7.43±1.051)mm,P<0.01].The proportion of type A endometrium was significantly higher than that of the control group(52.0%vs 32.7%,P<0.05).The progesterone level in luteal phase was significantly higher than that in the control group[(11.00±1.508)ng/mL vs(10.23±2.278)ng/mL,P<0.05].The ovulation rate and the cumulative clinical pregnancy rate were significantly higher than that of the control group(88.4%vs 79.7%,P<0.05,and 40.6%vs 22.2%,P<0.05),respectively.Conclusions Dingkundan can cooperate with estrogen in the treatment of thin endometrium in the clomiphene reduced ovulation cycle,improve the endometrium type,and increase the ovulation rate of clomiphene,luteal function and clinical pregnancy rate.
作者
金凤羽
阮祥燕
秦爽
许新
杨瑜
谷牧青
李妍秋
杜娟
程姣姣
尹晓丹
Jin Fengyu;Ruan Xiangyan;Qin Shuang;Xu Xin;Yang Yu;Gu Muqing;Li Yanqiu;Du Juan;Cheng Jiaojiao;Yin Xiaodan(Department of Gynecological Endocrinology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University/Beijing Maternal and Child Health Care Hospital,Beijing 100026,China;Department of Traditional Chinese Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University/Beijing Maternal and Child Health Care Hospital,Beijing 100026,China)
出处
《首都医科大学学报》
CAS
北大核心
2023年第4期550-554,共5页
Journal of Capital Medical University
基金
北京市属医院科研培育计划项目(PZ2019031)
北京市医院管理中心“登峰”人才培养计划项目(DFL20181401)。
关键词
氯米芬
薄型子宫内膜
内膜型态
定坤丹
排卵
妊娠
clomiphene
thin endometrium
endometrium type
Dingkun Pill
ovualtion
pregnance
