摘要
目的:探讨血清血管内皮生长因子(VEGF)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)和细胞角蛋白19片段(CYFRA21-1)在中晚期非小细胞肺癌调强放疗联合化疗前后的表达变化及与近期疗效的关系。方法:选取2021年7月至2022年10月河南省肿瘤医院放疗科行调强放疗联合化疗方法治疗的非小细胞肺癌的患者60例,采用酶联免疫吸附(ELISA)法检测血清VEGF,采用化学发光微粒子免疫检测法检测血清CEA、NSE和CYFRA21-1治疗前后的水平,比较不同的组织学类型和临床分期时4种肿瘤标志物的表达情况,分析治疗前后肿瘤标志物水平的变化以及肿瘤标志物水平与近期疗效的关系。结果:血清CEA在腺癌患者中表达的水平高于鳞癌(P<0.05),CYFRA21-1在腺癌患者中表达的水平低于鳞癌(P<0.05)。治疗前Ⅳ期患者血清VEGF水平高于Ⅲ期患者(P<0.05)。血清VEGF、CEA、NSE和CYFRA21-1治疗后水平均低于治疗前(P<0.05)。治疗结束后,有效39例,无效21例,治疗有效患者的血清VEGF、CEA和CYFRA21-1低于治疗无效的患者(P<0.05)。结论:与肺鳞癌患者比较,肺腺癌患者血清CEA表达水平高,CYFRA21-1表达水平低,治疗前Ⅳ期患者血清VEGF水平高于Ⅲ期患者;调强放疗联合化疗后4种肿瘤标志物水平均降低,尤其是治疗后血清VEGF、CEA和CYFRA21-1的水平与近期疗效相关,可对非小细胞肺癌治疗效果有预测价值。
Objective:To investigate the expression changes of serum vascular endothelial growth factor(VEGF),carcinoembryonic antigen(CEA),neuron-specific enolase(NSE)and cytokeratin-19-fragment(CYFRA21-1)before and after intensity modulated radiotherapy combined with chemotherapy in advanced non-small cell lung cancer(NSCLC)and their relationship with short-term curative effects.Methods:60 NSCLC patients treated with intensity-modulated radiotherapy combined with chemotherapy were selected from the radiotherapy department of Henan Cancer Hospital from July 2021 to October 2022.Enzyme-linked immunosorbent assay(ELISA)was used to detect serum VEGF levels,while chemiluminescence microparticle immunoassay was used to detect CEA,NSE,and CYFRA21-1 levels before and after treatment.The expression of the four tumor markers in different histological types and clinical stages were compared,and changes in tumor marker levels before and after treatment and their relationship with short-term curative effects were analyzed.Results:Serum CEA expression level of adenocarcinoma patients was higher than that of squamous cell carcinoma patients(P<0.05).Conversely,serum CYFRA21-1 expression level of adenocarcinoma patients was lower than that of squamous cell carcinoma patients(P<0.05).Before treatment,serum VEGF level of patients with stageⅣcancer was higher than that of stageⅢpatients(P<0.05).After treatment,serum VEGF,CEA,NSE,and CYFRA21-1 levels were all reduced compared to pre-treatment levels(P<0.05).After finishing treatment,39 cases were effective,while 21 cases were ineffective.Furthermore,serum VEGF,CEA,and CYFRA21-1 levels of patients with effective treatment were lower than those of patients with ineffective treatment(P<0.05).Conclusion:Compared to squamous cell carcinoma patients,the expression level of CEA is higher and expression level of CYFRA21-1 is lower in lung adenocarcinoma patients.Serum VEGF level of patients with stageⅣcancer are higher than that of stageⅢcancer prior to treatment.After treatment with intensity
作者
付文慧
刘雯
黄毅力
刘劲松
FU Wenhui;LIU Wen;HUANG Yili;LIU Jinsong(Department of Imaging and Nuclear Medicine,Third Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,China;Department of Radiotherapy,Henan Cancer Hospital,Zhengzhou 450003,China)
出处
《现代医学》
2023年第4期501-505,共5页
Modern Medical Journal
关键词
非小细胞肺癌
调强放疗
化疗
肿瘤标志物
non-small cell lung cancer
intensity modulated radiotherapy
chemotherapy
tumor markers
