摘要
目的探讨益生菌辅助治疗对非霍奇金淋巴瘤患者肠道微生态失衡、T淋巴细胞亚群及食欲调节因子的影响。方法前瞻性选择2022年6月至12月来常州市第一人民医院诊治的非霍奇金淋巴瘤患者120例,根据随机数字表法将患者分为对照组(n=60)与观察组(n=60)。对照组行CHOP方案化疗,观察组在对照组基础上给予双歧杆菌四联活菌片,两组治疗疗程相同。比较两组的临床疗效,对比两组治疗前后的肠道微生态失衡情况、T淋巴细胞亚群水平、ghrelin及leptin水平,对比两组患者治疗期间的不良反应发生情况。结果观察组的缓解率为81.67%,明显高于对照组(61.67%),差异有统计学意义(P<0.05)。治疗后,观察组的肠球菌、肠杆菌、梭杆菌、拟杆菌水平低于对照组,双歧杆菌、乳杆菌高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组肠道微生态失衡比例为8.33%低于对照组(33.33%),差异有统计学意义(P<0.05)。治疗后,观察组的CD4^(+)、CD4^(+)/CD8^(+)明显高于对照组,CD8^(+)明显低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组的ghrelin水平高于对照组,leptin水平低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组的恶心呕吐、血红蛋白降低、周围神经症状比例明显低于对照组,差异均有统计学意义(P<0.05);两组的白细胞降低、肝损害、血小板降低比例比较,差异均无统计学意义(P>0.05)。结论益生菌辅助治疗可改善非霍奇金淋巴瘤患者的肠道微生态失衡、T淋巴细胞亚群及食欲调节因子,降低不良反应发生率。
Objective To investigate the effects of probiotic-assisted therapy on intestinal microecological imbalance,T lymphocyte subsets and appetite regulatory factors in patients with non-Hodgkin's lymphoma.Methods A total of 120 patients with non-Hodgkin's lymphoma admitted to The First People's Hospital of Changzhou from June to December 2022 were prospectively selected.According to random number table method,120 patients were randomly divided into control group(n=60)and observation group(n=60).The control group were received CHOP chemotherapy,and the observation group were received bifidus quadruple viable tablet on the base of control group.The clinical efficacy,intestinal microecological imbalance,T lymphocyte subsets,ghrelin and leptin levels before and after treatment,and the occurrence of adverse reactions in two groups during treatment were compared.Results The remission rate of the observation group was 81.67%,which was significantly higher than that of the control group(61.67%),the difference was statistically significant(P<0.05).After treatment,the levels of Enterococcus,Enterobacteriaceae,Fusobacterium and Bacteroides in the observation group were lower than those in the control group,and the levels of Bifidobacterium and Lactobacillus were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the proportion of intestinal microbiota imbalance in the observation group was 8.33%,which was lower than the control group(33.33%),the difference was statistically significant(P<0.05).After treatment,the CD4^(+)and CD4^(+)/CD8^(+)levels in the observation group were significantly higher than those in the control group,while CD8^(+)levels were significantly lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the ghrelin level in the observation group was higher than that in the control group,while the leptin level was lower than that in the control group,the differences were statistically significant(P<0.05
作者
顾红柳
陈璐
沙琦
付瑜
仇怡
张敏
贺白
GU Hong-liu;CHEN Lu;SHA Qi(Department of Clinical Nutrition,The First People's Hospital of Changzhou,Changzhou Jiangsu 213003,China)
出处
《临床和实验医学杂志》
2023年第11期1178-1182,共5页
Journal of Clinical and Experimental Medicine
基金
江苏省第五期“333”工程资助项目(编号:BRA2017116)。
