摘要
目的探讨胆碱酯酶(CHE)在乙型病毒性肝炎患者中的表达水平及对进展为肝硬化的预测价值。方法选取2020年11月至2021年12月信阳职业技术学院附属医院收治的乙型病毒性肝炎患者126例为研究对象,纳入观察组;另取同期体检健康者45例为健康对照组,比较两组受试者一般资料及CHE表达情况,对观察组患者随访1 a,根据随访期间临床诊断结果分为非肝硬化组和肝硬化组,比较两组临床资料,采用logistic回归分析乙肝进展为肝硬化的影响因素;根据受试者工作特征(ROC)曲线,评价CHE对乙型病毒性肝炎患者进展为肝硬化的预测价值。结果健康对照组性别、年龄与观察组比较,差异无统计学意义(P>0.05);观察组患者血清CHE水平低于对照组,差异有统计学意义(P<0.05);随访1 a,126例乙型病毒肝炎患者中89例患者未进展为肝硬化,占比70.63%,37例患者进展为肝硬化,占比29.37%;肝硬化组患者年龄、性别、饮酒情况、抗病毒治疗、纤维蛋白原(FIB)、白蛋白(ALB)与非肝硬化组比较,差异无统计学意义(P>0.05);肝硬化组患者丙氨酸氨基转移酶(ALT)、活化部分凝血活酶时间(APTT)、谷草转氨酶(GOT)水平均高于非肝硬化组,血小板计数(PLT)、CHE水平低于非肝硬化组(P<0.05);经logistic回归分析,结果显示,APTT是乙肝患者进展为肝硬化的危险因素(OR>1,P<0.05),PLT、CHE是保护因素(OR<1,P<0.05);绘制ROC曲线,结果显示,CHE水平预测乙肝患者进展为肝硬化的AUC>0.7,具有一定的预测价值。结论CHE在乙肝患者中呈低表达,是乙肝患者进展为肝硬化的影响因素,可有效预测患者疾病进展情况。
Objective To investigate the expression of cholinesterase(CHE)in patients with hepatitis B and its predictive value in the progression of cirrhosis.Methods A total of 126 patients with hepatitis B admitted to the Affiliated Hospital of Xinyang Vocational and Technical College from November 2020 to December 2021 were included in the observation group.Another 45 healthy people in the same period of physical examination were taken as the healthy control group.The general data and CHE expression of the two groups of subjects were compared.The patients in the observation group were followed up for one year.According to the clinical diagnosis results during the follow-up period,they were divided into non-cirrhosis group and cirrhosis group.The clinical data of the two groups were compared and the influencing factors were analyzed by logistic regression.The predictive value of CHE on the progression of hepatitis B patients to cirrhosis was evaluated according to the working characteristic(ROC)curve of subjects.Results There was no statistical difference in sex and age between the healthy control group and the observation group(P>0.05).The level of serum CHE in the observation group was lower than that in the control group,with a statistical difference(P<0.05).During the follow-up period of one year,89 of 126 patients with hepatitis B did not progress to cirrhosis,accounting for 70.63%,and 37 patients progressed to cirrhosis,accounting for 29.37%.There was no statistical difference in age,sex,alcohol consumption,antiviral therapy,fibrinogen(FIB)and albumin(ALB)between the cirrhosis group and the non-cirrhosis group(P>0.05).The levels of activated partial thromboplastin time(APTT),alanine aminotransferase(ALT)and glutamic oxaloacetic transaminase(GOT)in cirrhosis group were higher than those in non-cirrhosis group,and the levels of platelet count(PLT)and CHE were lower than those in non-cirrhosis group,with a statistical significant difference(P<0.05).The results of logistic regression analysis showed that APTT was the ri
作者
刘雪梅
LIU Xuemei(Department of Clinical Laboratory,the Affiliated Hospital of Xinyang Vocational and Technical College,Xinyang 464000,China)
出处
《河南医学研究》
CAS
2023年第13期2378-2381,共4页
Henan Medical Research
