摘要
目的 分析载脂蛋白B(ApoB)/载脂蛋白A1(ApoA1)表达水平与重症急性胰腺炎患者短期预后的关系。方法 前瞻性纳入信阳职业技术学院附属医院2020年8月至2022年8月收治的96例重症急性胰腺炎患者,所有患者于入院第1天检测ApoB、ApoA1、白细胞计数(WBC)、C反应蛋白(CRP)、甘油三酯(TG)、总胆固醇(TC)水平,并计算ApoB/ApoA1比值。96例重症急性胰腺炎患者入院后均随访28 d统计短期预后情况;根据短期预后情况,将28 d内病死的患者纳入病死组,其余患者纳入存活组。比较两组患者一般资料、ApoB/ApoA1水平,应用点二列相关性,分析ApoB/ApoA1与重症急性胰腺炎短期预后的关系,并绘制受试者工作特征(ROC)曲线分析ApoB/ApoA1比值对重症胰腺炎患者短期预后的预测价值。结果 入院后28 d内,96例重症急性胰腺炎患者中病死28例(29.17%)。病死组体温高于对照组,差异有统计学意义(P<0.05);两组其他一般资料及TG、TC、WBC水平比较,差异无统计学意义(P>0.05);病死组ApoB/ApoA1比值、CRP水平高于存活组,差异有统计学意义(P<0.05)。经点二列相关性分析,ApoB/ApoA1比值、CRP水平与重症急性胰腺炎患者短期预后情况呈正相关(r>0,P<0.05)。绘制ROC曲线,结果显示,ApoB/ApoA1预测重症急性胰腺炎患者短期预后的曲线下面积为0.721,且ApoB/ApoA1取1.745时可获得最佳预测价值(敏感度为0.893、特异性为0.529、约登指数为0.422)。结论 ApoB/ApoA1与重症急性胰腺炎患者的短期预后有关,且ApoB/ApoA1对短期预后结局的预测具有一定价值,ApoB/ApoA1比值越高,提示患者病死风险越大。
Objective To analyze the relationship between the expression of apolipoprotein-B(ApoB)/apolipoprotein-A1(ApoA1)ratio and the short-term prognosis of patients with severe acute pancreatitis.Methods A total of 96 patients with severe acute pancreatitis admitted to the Affiliated Hospital of Xinyang Vocational and Technical College from August 2020 to August 2022 were prospectively included.The levels of ApoB,ApoA1,white blood cell count(WBC),C-reactive protein(CRP),triglyceride(TG)and total cholesterol(TC)were measured in all patients on the first day of admission,and the ratio of ApoB/ApoA1 was calculated.A total 96 patients with severe acute pancreatitis were followed up for 28 days after admission and the short-term prognosis was analyzed.According to the short-term prognosis,patients who died within 28 days were included in the death group,and the remaining patients were included in the survival group.The baseline data and level of ApoB/ApoA1 were compared between the two groups.The relationship between ApoB/ApoA1 and short-term prognosis of patients with severe acute pancreatitis was analyzed by using point binary correlation,and receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of the expression of ApoB/ApoA1 ratio on the short-term prognosis of patients with severe acute pancreatitis.Results Within 28 days after admission,28(29.17%)of 96 patients with severe acute pancreatitis died.Compared with control group,the body temperature in the death group was higher,with a statistically significant difference(P<0.05).There was no statistically significant difference between the two groups in other baseline data and TG,TC and WBC levels(P>0.05).Compared with survival group,the ratio of ApoB/ApoA1 and level of CRP in the death group were higher,with a statistically significant difference(P<0.05).Through point binary correlation analysis,ApoB/ApoA1 ratio and CRP level were positively correlated with short-term prognosis of patients with severe acute pancreatitis(r>0,P<0.05).The ROC
作者
刘雪梅
LIU Xuemei(Department of Clinical Laboratory,the Affiliated Hospital of Xinyang Vocational and Technical College,Xinyang 464000,China)
出处
《河南医学研究》
CAS
2023年第9期1644-1647,共4页
Henan Medical Research
关键词
重症急性胰腺炎
载脂蛋白B
载脂蛋白A1
短期预后
severe acute pancreatitis
apolipoprotein-B
apolipoprotein-A1
short-term prognosis
