摘要
目的:观察金莲花颗粒联合布地奈德治疗急性咽炎的临床疗效及对血清炎症因子水平的影响。方法:对90例急性咽炎进行回顾性分析,根据治疗方式的不同将其分为对照组和观察组各45例。对照组给予吸入用布地奈德混悬液治疗,观察组在对照组的基础上加用金莲花颗粒治疗。比较2组临床疗效、症状缓解时间、不良反应发生率,以及治疗前后中医证候评分、血清炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)]水平。结果:观察组总有效率为91.11%,对照组为82.22%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组咽痛、咽干灼热、黏膜充血、发热、微恶寒、咳嗽痰黄等中医证候评分比较,差异无统计学意义(P>0.05);治疗后,2组上述各项中医证候评分均较治疗前降低(P<0.05),且观察组各项评分均低于对照组(P<0.05)。治疗后,观察组咽痛、咽干、咽部灼热症状缓解时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,2组血清IL-6、hs-CRP、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,2组上述各项炎症因子水平均较治疗前降低(P<0.05),且观察组3项指标均低于对照组(P<0.05)。观察组不良反应发生率为8.88%,对照组为17.77%,2组比较,差异有统计学意义(P<0.05)。结论:金莲花颗粒联合布地奈德治疗急性咽炎可提高疗效,有效抑制机体炎症反应,降低中医证候评分和不良反应发生率,加速病情康复,且安全性较高。
Objective:To observe the clinical effect of Jinlianhua Granules combined with Budesonide on acute pharyngitis and its effect on levels of inflammatory factors in serum.Methods:A total of 90 cases of patients with acute pharyngitis were given retrospective analysis and divided into the control group and the observation group according to their different treatment methods,with 45 cases in each group.The control group was treated with Budesonide Suspension for Inhalation,and the observation group was additionally treated with Jinlianhua Granules based on the treatment of the control group.The traditional Chinese medicine(TCM)syndrome scores and levels of inflammatory factors in serum[C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]before and after treatment,as well as the clinical effects,relief time of symptoms,and incidence of adverse reactions were compared between the two groups.Results:The total effective rate was 91.11%in the observation group and 82.22%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of TCM syndrome scores including pharyngalgia,dryness and scorching of the pharynx,mucous hyperemia,fever,mild aversion to cold,and cough and yellow sputum between the two groups(P>0.05);after treatment,the above TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).The relief time of symptoms including pharyngalgia,dryness and scorching of the pharynx in the observation group was shorter than that in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of IL-6,hs-CRP and TNF-αin serum between the two groups(P<0.05);after treatment,the above levels of inflammatory factors in the two groups were decreased when compared with those before treatment(P<0.05
作者
徐开睿
黄武
章誉耀
XU Kairui;HUANG Wu;ZHANG Yuyao
出处
《新中医》
CAS
2023年第10期91-95,共5页
New Chinese Medicine
关键词
急性咽炎
金莲花颗粒
布地奈德
中医证候评分
炎症因子
Acute pharyngitis
Jinlianhua Granules
Budesonide
Traditional Chinese medicine syndrome scores
Inflammatory factors
