摘要
目的:探讨丙种球蛋白联合布地奈德雾化治疗新生儿肺炎的效果。方法:选取2019年12月—2021年12月我院收治的80例肺炎新生儿作为研究对象,采用随机数字表法分为观察组和对照组,每组40例,对照组予以布地奈德雾化治疗,观察组予以丙种球蛋白联合布地奈德雾化治疗,比较两组临床疗效、症状消失时间以及住院时间、炎性因子指标[白细胞介素-6(IL-6)水平、肿瘤坏死因子(TNF-α)水平、γ干扰素(IFN-γ)]以及肺功能指标[用力肺活量(FVC)、第1秒用力呼气量(FEV 1)以及第1秒用力呼气量占用力肺活量比率(FEV1/FVC)]。结果:观察组临床总有效率为97.50%,高于对照组的85.00%(P<0.05);观察组症状消失时间以及平均住院时间均短于对照组(P<0.05);观察组IL-6、IFN-γ、TNF-α水平低于对照组(P<0.05);观察组FVC、FEV 1、FEV 1/FVC水平高于对照组(P<0.05)。结论:丙种球蛋白联合布地奈德雾化治疗新生儿肺炎治疗效果较好,可明显缩短临床症状改善时间,有效降低炎性因子水平,改善肺功能,临床应用性良好。
Objective:To investigate the effect of gamma globulin combined with budesonide in the treatment of neonatal pneumonia.Methods:A total of 80 cases of neonatal pneumonia admitted to our hospital from December 2019 to December 2021 were selected as the research objects.They were randomly divided into observation group and control group,with 40 cases in each group.The control group was treated with budesonide atomization,and the observation group was treated with gamma globulin combined with budesonide atomization.The clinical efficacy,symptom disappearance time,hospitalization time,inflammatory factor indexes[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)]and pulmonary function indexes[forced vital capacity(FVC),forced expiratory volume in the first second(FEV1)and forced expiratory volume in the first second to forced vital capacity ratio(FEV1/FVC)]were compared between the two groups.Results:The total clinical effective rate of the observation group was 97.50%,which was higher than 85.00%of the control group(P<0.05).The symptom disappearance time and the average hospitalization time of the observation group were shorter than those of the control group(P<0.05).The levels of IFN-γand TNF-αwere lower than those in the control group(P<0.05).The levels of FVC,FEV1 and FEV 1/FVC in the observation group were higher than those in the control group(P<0.05).Conclusion:Atomization of gamma globulin combined with budesonide in the treatment of neonatal pneumonia has a good therapeutic effect,which can significantly shorten the improvement time of clinical symptoms,effectively reduce the level of inflammatory factors,improve lung function,and has good clinical application.
作者
武向宇
王红榕
WU Xiangyu;WANG Hongrong(Department of Pediatric,Tianjin Hongqiao Hospital,Tianjin 300131,China)
出处
《中国药物滥用防治杂志》
CAS
2023年第6期1055-1058,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
丙种球蛋白
布地奈德
新生儿肺炎
疗效
炎性指标
肺功能
Gamma globulin
Budesonide
Neonatal pneumonia
Curative effect
Inflammatory index
Lung function
