摘要
目的探讨消黄汤泡浴联合蓝光照射在新生儿高胆红素血症中的应用情况。方法为前瞻性随机对照试验,研究对象为南康区妇幼保健院2021年9月至2022年9月治疗的65例新生儿高胆红素血症患儿,以随机数字表法分为对照组(n=33)与研究组(n=32),对照组接受蓝光照射治疗,研究组在蓝光照射基础上接受消黄汤泡浴,两组均治疗7 d。记录两组腹胀、便秘、发热、皮肤黄染等症状好转时间及不良反应发生率,并比较两组治疗前后血清谷草转氨酶(AST)、谷丙转氨酶(ALT)、神经元特异性烯醇化酶(NSE)、S100B蛋白水平。结果研究组腹胀、便秘、发热及皮肤黄染好转时间分别为(2.82±0.64)d、(3.02±0.52)d、(2.12±0.66)d、(3.35±0.60)d,均短于对照组的(3.67±0.42)d、(3.80±0.45)d、(3.08±0.76)d、(4.14±0.68)d,差异有统计学意义(P<0.05);治疗后,研究组血清总胆红素、间接胆红素水平分别为(126.45±16.57)μmol/L、(128.46±12.33)μmol/L,均显著低于对照组的(140.52±18.62)μmol/L、(136.58±14.45)μmol/L,差异有统计学意义(P<0.05);治疗后,两组血清AST、ALT、NSE、S100B水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);对照组与研究组不良反应发生率分别为15.15%、6.25%,差异无统计学意义(P>0.05)。结论消黄汤泡浴联合蓝光照射在新生儿高胆红素血症中的治疗效果显著,可改善患儿临床症状、降低胆红素水平、预防肝脏或神经系统损伤。
Objective To explore the application of xiaohuang decoction bath combined with blue light irradiation in neonatal hyperbilirubinemia.Methods This study was a prospective randomized controlled trial.The subjects were 65 neonatal hyperbilirubinemia who were treated in Nankang Maternal and Child Health Hospital from September 2021 to September 2022.They were divided into the control group(n=33)and the study group(n=32)by random number table method.The control group received blue light irradiation treatment,and the study group received xiaohuang decoction bath on the basis of blue light irradiation.Both groups were treated for 7 days.The improvement time of abdominal distention,constipation,fever,skin yellowing and the incidence of adverse reactions were recorded,and the serum levels of glutamic oxaloacetic transaminase(AST),glutamic pyruvic transaminase(ALT),neuron specific enolase(NSE),S100B protein were compared between the two groups before and after treatment.Results The improvement time of abdominal distension,constipation,fever and skin yellowing in the study group were(2.82±0.64)d,(3.02±0.52)d,(2.12±0.66)d and(3.35±0.60)d,respectively,which were shorter than those in the control group(3.67±0.42)d,(3.80±0.45)d,(3.08±0.76)d and(4.14±0.68)d,with a statistical significant difference(P<0.05).After treatment,the levels of serum total bilirubin and indirect bilirubin in the study group were(126.45±16.57)μmol/L and(128.46±12.33)μmol/L,respectively,which were significantly lower than those in the control group(140.52±18.62)μmol/L and(136.58±14.45)μmol/L,with a statistical significant difference(P<0.05).After treatment,the average levels of serum AST,ALT,NSE,and S100B levels in the two groups were lower than before treatment,and the study group was lower than the control group,with a statistical significant difference(P<0.05).The incidences of adverse reactions in the control group and the study group were 15.15%and 6.25%respectively,and there was no statistical significant difference(P>0.05).Conclusion
作者
刘学
LIU Xue(Ganzhou Nankang Maternal and Child Health Hospital,Ganzhou Jiangxi 341400,China)
出处
《药品评价》
CAS
2023年第4期441-445,共5页
Drug Evaluation
关键词
高胆红素血症
新生儿
浴疗学
消黄汤
蓝光治疗
总胆红素
直接胆红素
Hyperbilirubinemia,neonatal
Balneology
Xiaohuang decoction
Blue light therapy
Total bilirubin
Direct bilirubin
