摘要
目的 探讨克罗恩病(Crohn’s disease, CD)患者血清25(OH)D水平与病变部位、疾病活动性、肠道炎症程度以及激素治疗等因素的相关性。方法 收集2020年1月至2022年12月在南京鼓楼医院就诊的CD患者97例,及同期在体检中心进行健康体检者79例。比较两组人群25(OH)D水平的差异。记录CD患者就诊时的一般资料、临床表现、肠镜检查结果、白细胞计数(WBC)、血红蛋白(Hb)、C反应蛋白(CRP)、血沉(ESR)、血清白蛋白(ALB)水平及用药情况,并分析25(OH)D水平与其相关性。结果 CD组的25(OH)D水平显著低于健康对照组[12.87(3.00~33.84)ng/mL vs 19.97(16.28~39.61)ng/mL](Z=-8.518,P<0.001),回结肠病变的CD患者25(OH)D水平显著低于回肠病变者[11.07(3.00~33.84)ng/mL vs 14.68(3.00~27.59)ng/mL](Z=-2.081,P=0.037),回结肠病变的CD患者25(OH)D水平明显低于结肠病变者[11.07(3.00~33.84)ng/mL vs 12.63(5.29~24.54)ng/mL](Z=-0.177,P=0.860),缓解期患者25(OH)D水平明显高于轻度活动期患者[13.51(3.00~33.84)ng/mL vs 11.91(5.81~24.54)ng/mL](Z=-0.430,P=0.668),缓解期患者25(OH)D水平明显高于中度活动期患者[13.51(3.00~33.84)ng/mL vs 9.66(3.37~17.28)ng/mL](Z=-0.909,P=0.363),重度炎症组25(OH)D水平显著低于轻度炎症组[10.79(3.00~19.01)ng/mL vs 17.96(3.00~22.98)ng/mL](Z=-2.888,P<0.05),重度炎症组25(OH)D水平显著低于中度炎症组[10.79(3.00~19.01)ng/mL vs 13.39(3.37~33.84)ng/mL](Z=-2.502,P<0.05),Logistic回归回归分析显示,CRP≥8mg/L,ESR≥20mm/1h、激素治疗是VD缺乏的危险因素。结论 CD患者的VD水平降低,VD水平与病变部位、疾病活动度及炎症程度相关。感染、激素治疗是CD患者VD缺乏的危险因素,建议在CD的治疗过程中注意VD的合理补充。
Objective To explore the correlation between serum 25(OH)D and the intestinal lesion location,disease activity,intestinal inflammation and hormone therapy in patients with Crohn’s disease(CD).Methods 97 CD patients who visited Nanjing Drum Tower Hospital from January,2020 to December,2022 were collected for the study,while 79 healthy subjects who underwent health examinations at the Examination Center during the same period were selected as the control group.We evaluated the differences in 25(OH)D level between these two groups.We collected the general information,clinical manifestations,colonoscopy results,white blood cell count(WBC),hemoglobin(Hb),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),serum albumin(ALB)levels,and medication status of CD patients,and analyzed the correlation between 25(OH)D levels and their inspection results.Results Levels of 25(OH)D in the CD group were significantly lower than those in the healthy control group[12.87(3.00-33.84)ng/mL vs 19.97(16.28-39.61)g/mL](Z=-8.518,P<0.001),and levels of 25(OH)D in CD patients with ileocolic lesions were significantly lower than those with ileum lesions[11.07(3.00-33.84)ng/mL vs 14.68(3.00-27.59)ng/mL](Z=-2.081,P=0.037).Levels of 25(OH)D in CD patients with ileocolic lesions were significantly lower than those with colon lesions[11.07(3.00-33.84)ng/mL vs 12.63(5.29-24.54)ng/mL](Z=-0.177,P=0.860).Levels of 25(OH)D in remission patients were significantly higher than those in mild active patients[13.51(3.00-33.84)ng/mL vs 11.91(5.81-24.54)ng/mL](Z=-0.430,P=0.668).Levels of 25(OH)D in patients in the remission stage were significantly higher than those in patients in the moderate active stage[13.51(3.00-33.84)ng/mL vs 9.66(3.37-17.28)ng/mL](Z=-0.909,P=0.363),and levels of 25(OH)D in the severe inflammation group were significantly lower than those in the mild inflammation group[10.79(3.00-19.01)ng/mL vs 17.96(3.00-22.98)ng/mL](Z=-2.888,P<0.05).Levels of 25(OH)D in the severe inflammation group were significantly lower than those in th
作者
高硕
张燕
郭利利
周万青
徐学静
GAO Shuo;ZHANG Yan;GUO Lili;ZHOU Wanqing;XU Xuejing(Department of Laboratory Medicine,Nanjing Drum Tower Hospital,the AffiliatedHospital of Nanjing University Medical School,Nanjing 210008,China)
出处
《标记免疫分析与临床》
CAS
2023年第4期583-588,共6页
Labeled Immunoassays and Clinical Medicine
关键词
克罗恩病
维生素D
炎症程度
Crohn’s disease
Vitamin D
Degree of inflammation
