摘要
目的:探讨中老年人群脂质蓄积指数(LAP)与高血压患病的剂量-反应关系。方法:选取中国健康与退休纵向研究(CHARLS)2011年的基线数据及2015年的追踪数据。采用多因素Logistic回归模型探讨LAP与新发高血压之间的关系。通过建立3个模型来矫正调整8个因素(年龄、性别、受教育程度、居住地点、婚姻状况、吸烟状况、饮酒状况和睡眠时间)对结果造成的潜在可能影响,并限制立方样条模型来检查可能的非线性关联,将LAP与高血压患病的剂量-反应关系可视化。结果:共纳入合格参与者4 808人,其中新发高血压823人,LAP最高组(Q_(4))新发生高血压的风险最高117%[OR=2.17,95%CI(1.56,2.47)]。使用限制性三次样条回归分析显示,LAP与高血压发病率之间存在剂量反应关系(P<0.001),且为非线性关系(P<0.001)。将LAP作为连续性变量进行计算,在调整潜在混杂因素后,LAP每上升1个四分位数,新发生高血压的患病风险增加5%。结论:LAP为高血压的危险因素且二者存在剂量-反应关系,LAP可作为筛查中老年人新发高血压患病风险的有效指标。
Objective:To investigate the relationship between lipid accumulation index(LAP)and hypertension prevalence in the middleaged and elderly population.Methods:Data were selected from the China Health and Retirement Longitudinal Study(CHARLS)2011 baseline data and 2015 follow-up data.Multifactorial Logistic regression model were used to explore the relationship between LAP and new-onset hypertension.The dose-response relationship between LAP and hypertension prevalence was visualized by building three models to correct for potential possible effects of eight factors(age,sex,education,residence location,marital status,smoking status,drinking status,and sleep duration)on the outcome,and by to examine possible nonlinear associations.restricting the cubic spline model.Results:A total of 4808 study subjects were included,including 823 with new-onset hypertension,and the group with the highest LAP index(Q4)showed the highest risk of new-onset hypertension by 117%(OR=2.17,95%CI 1.56-2.47).Analysis using restricted three-sample regression showed a dose-response relationship between the LAP index and the incidence of hypertension(P<0.001)and a nonlinear relationship(P<0.001).Using the LAP as a continuous variable,the risk of developing new hypertension increased by 5%for each quartile increase in the LAP,after adjusting for potential confounders.Conclusion:LAP is a risk factor for hypertension and there is a dose-response relationship,and LAP can be used as a valid indicator to screen for the new-onset hypertension in middleaged and elderly people.
作者
钱涛铭
刘莉
邹国良
韩宇博
全振华
QIAN Taoming;LIU Li;ZOU Guoliang;HAN Yubo;QUAN Zhenhua(Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China)
出处
《中西医结合心脑血管病杂志》
2023年第13期2439-2443,共5页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
国家自然科学基金面上项目(No.82074346)
黑龙江中医药大学优秀青年学术带头人支持计划项目。
关键词
新发高血压
中老年人群
脂质蓄积指数
剂量-反应关系
new-onset hypertension
middle-aged and elderly population
lipid accumulation index
dose-response relationship
