摘要
目的探讨血维生素D、尿酸水平与维持性血液透析(MHD)患者动脉钙化的相关性。方法回顾性选取2019年3月至2021年3月在首都医科大学大兴教学医院行MHD治疗的120例患者作为研究对象,采用X线检测患者动脉钙化情况,应用多因素Logistic回归分析影响MHD患者动脉钙化的危险因素。结果120例MHD患者按照动脉钙化积分分为无钙化组(43例,占35.83%)、轻度钙化组(16例,占13.33%)、中度钙化组(42例,占35.00%)和严重钙化组(19例,占15.83%),各组透析龄、血维生素D、血尿酸、血清钙、血清磷、全段甲状旁腺激素(iPTH)和动脉钙化积分比较差异均有统计学意义(P<0.05)。120例MHD患者依据血维生素D水平分为血维生素D缺乏组(84例,占70.00%)和血维生素D正常组(36例,占30.00%),血维生素D缺乏组血清钙和血清磷水平低于血维生素D正常组[(2.53±0.28)mmol/L比(3.15±0.31)mmol/L、(1.83±0.26)mmol/L比(2.07±0.31)mmol/L];血尿酸和动脉钙化积分高于血维生素D正常组[(512.41±65.21)μmol/L比(311.94±72.56)μmol/L、(6.92±2.34)分比(2.18±2.01)分],差异均有统计学意义(P<0.05)。120例MHD患者根据血尿酸水平分为高尿酸血症组(77例,占64.17%)和血尿酸正常组(43例,占35.83%),高尿酸血症组血维生素D水平低于血尿酸正常组[(12.28±5.18)μg/L比(28.84±4.69)μg/L];iPTH和动脉钙化积分高于血尿酸正常组[(372.45±90.31)ng/L比(291.60±98.52)ng/L、(6.22±2.52)分比(2.72±2.63)分],差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果表明,血维生素D和尿酸水平是影响MHD患者动脉钙化的危险因素(P<0.05)。结论血维生素D和尿酸水平与MHD患者动脉钙化相关,是引发患者动脉钙化的危险因素。
Objective To investigate the correlation between serum Vitamin D,uric acid levels and arterial calcification in maintenance hemodialysis patients.Methods A total of 120 patients who received MHD treatment in Daxing Teaching Hospital,Capital Medical University,from March 2019 to March 2021 were retrospectively selected as research subjects,and their general clinical data were recorded in detail.X-ray was used to detect the arterial calcification of patients.Multivariate Logistic regression was used to analyze the risk factors of arterial calcification in MHD patients.Results According to the arterial calcification score,120 MHD patients were divided into non-calcification group(43 cases,35.83%),mild calcification group(16 cases,13.33%),moderate calcification group(42 cases,35.00%)and severe calcification group(19 cases,15.83%).There were significant differences in dialysis years,serum Vitamin D,serum uric acid,serum calcium,serum phosphorus,intact parathyroid hormone(iPTH)and arterial calcification score among the four groups(P<0.05).According to serum Vitamin D level,120 MHD patients were divided into deficient serum Vitamin D group(84 cases,70.00%)and normal serum Vitamin D group(36 cases,30.00%),serum calcium and phosphorus levels in the deficient serum Vitamin D group were lower than those in the normal serum Vitamin D group:(2.53±0.28)mmol/L vs.(3.15±0.31)mmol/L,(1.83±0.26)mmol/L vs.(2.07±0.31)mmol/L;serum uric acid and arterial calcification scores in the deficient serum Vitamin D group were higher than those in the normal serum Vitamin D group:(512.41±65.21)μmol/L vs.(311.94±72.56)μmol/L,(6.92±2.34)scores vs.(2.18±2.01)scores,there were statistical differences(P<0.05).One hundred and twenty MHD patients were divided into hyperuricemia group(77 cases,64.17%)and uric acid normal group(43 cases,35.83%)according to the level of serum uric acid,the serum Vitamin D level in the hyperuricemia group was lower than that in uric acid the normal group:(12.28±5.18)μg/L vs.(28.84±4.69)μg/L;and iPTH level a
作者
张红
周培一
王甲正
冯悦民
Zhang Hong;Zhou Peiyi;Wang Jiazheng;Feng Yuemin(Department of Nephrology,Daxing Teaching Hospital,Capital Medical University,Beijing 102600,China)
出处
《中国医师进修杂志》
2023年第6期538-542,共5页
Chinese Journal of Postgraduates of Medicine
关键词
维生素D
尿酸
血液透析滤过
动脉钙化
Vitamin D
Uric acid
Hemodiafiltration
Arterial calcification
