摘要
目的:探讨母亲口腔卫生状况与牙周情况对新生儿口腔微生物群落的影响。方法:检查并记录48名母亲的口腔卫生状况,根据母亲牙周状况及婴儿月龄,将受试者分为4组,其中牙周炎组1月龄17名,健康组1月龄18名,牙周炎组6月龄7名,健康组6月龄6名。通过对婴儿唾液样本的高通量测序,分析母亲牙周状况对同月龄婴儿口腔微生物多样性的影响。采用SPSS 23.0软件包对数据进行统计学分析。结果:2组1月龄婴儿与2组6月龄婴儿中,健康组的口腔微生物多样性高于牙周炎组,但无显著差异。1月龄时,放线放线杆菌种(Unclassified.Aggregatibacter)、瘤胃球菌(Unclassified.Ruminococcaceae)、分歧杆菌(Sp.Mycobacterium)等12种菌种的物种丰度在健康组与牙周炎组间存在显著差异;而6月龄时,仅奈瑟菌种(Elongata.Neisseria)在2组间存在显著差异。结论:母亲不同牙周状态对婴儿口腔内微生物物种多样性具有一定影响,1月龄婴儿与6月龄婴儿相比,该影响导致的菌种丰度差异更为显著。
PURPOSE:To explore whether oral hygiene and periodontal conditions of mothers had an impact on oral microbiota of newborns.METHODS:The oral health status of 48 mothers was examined and recorded.According to the mothers'periodontal status and the age of infants,the subjects were divided into 4 groups:one-month-old periodontitis group(n=17),one-month-old healthy group(n=18),six-month-old periodontitis group(n=7)and six-month-old healthy group(n=6).Through high-throughput sequencing of saliva samples of infants aged one month and six months,the impact of mother's periodontal status on oral microbial diversity of infants of the same month was analyzed.SPSS 23.0 software package was used for data analysis.RESULTS:In the two groups of one-month-old infants and the two groups of six-month-old infants,the oral microbial diversity in the healthy group was higher than that in the periodontitis group,but there was no significant difference.The species abundances of 12 species of Unclassified.Aggregatibacter,Unclassified.Ruminococcaceae,and Sp.Mycobacterium existed between the healthy group and the periodontitis group at the age of one month had significant difference.However,by the age of six months,only Elongata.Neisseria species was significantly different between the two groups.CONCLUSIONS:Different periodontal status of mothers has a certain influence on the microbial species diversity in the infant's oral cavity,and the difference in bacterial species abundance caused by this effect is more significant in one-month-old infants than in six-month-old infants.
作者
王力
徐睿
WANG Li;XU Rui(Department of Pediatric Dentistry,Dental Center of Jiading District,Shanghai 201800,China;Department of Endodontics and Periodontics,Dental Center of Jiading District,Shanghai 201800,China)
出处
《上海口腔医学》
CAS
北大核心
2023年第3期318-322,共5页
Shanghai Journal of Stomatology
关键词
牙周炎
唾液细菌
微生物多样性
Periodontitis
Saliva bacteria
Microbial diversity
