摘要
过氧化物还原酶6(PRDX6)是一类古老的抗氧化酶,属于过氧化物酶超家族成员。不同于其他家族成员,PRDX6仅表达单一的NH-2端保守半胱氨酸残基,并且是一种独特的双功能酶。PRDX6蛋白通过清除氧化剂、修复过氧化物细胞膜、参与磷脂代谢等保护细胞或组织,发挥损伤修复作用。越来越多证据表明,PRDX6在中枢神经系统疾病中能够发挥抗炎、抗氧化、抗凋亡等积极作用。本文就PRDX6的基本特性及其与中枢神经系统疾病的关系进行阐述,旨在为临床治疗提供新的靶点和策略。
Peroxiredoxin 6(PRDX6)is an ancient antioxidant enzyme belonging to the peroxidase superfamily.Unlike other family members,PRDX6 only expresses a single conserved cysteine residue at the NH-2 end and is a unique bifunctional enzyme.PRDX6 protein can protect cells or tissues by scavenging oxidants,repairing peroxide cell membranes and participating in phospholipid metabolism,and play a role in damage repair.More and more evidence shows that PRDX6 can play an active role in anti-inflammatory,anti-oxidation and anti-apoptosis in central nervous system diseases.This article reviews the basic characteristics of PRDX6 and its relationship with central nervous system diseases,aiming to provide new targets and strategies for clinical treatment.
作者
唐彬
刘凡昱
宗寿洋
万长春
TANG Bin;LIU Fanyu;ZONG Shouyang;WAN Changchun(Jinhu County People's Hospital,Huai'an 211600;School of Medicine Jiangsu University,Zhenjiang 212013,China)
出处
《临床医学研究与实践》
2023年第19期195-198,共4页
Clinical Research and Practice
