摘要
目的分析枸地氯雷他定联合西咪替丁治疗变态反应性皮肤病的疗效。方法选取2019年7月至2020年6月本院收治的100例变态反应性皮肤病患者作为研究对象,按照抽签法分为治疗组和对照组,每组50例。对照组给予枸地氯雷他定治疗,治疗组在对照组基础上联合西咪替丁治疗。比较两组临床疗效、炎症因子水平、趋化因子水平及免疫功能分子水平,不良反应发生情况,疗效感受评分及复发情况。结果治疗组治疗总有效率为94.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,治疗组血清白细胞介素-23(IL-23)、白细胞介素-33(IL-33)、肺部活化调节趋化因子/趋化因子配体-18(PARC/CCL-18)水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,治疗组CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,且CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。治疗组不良反应发生率为4.00%,低于对照组的18.00%,差异具有统计学意义(P<0.05)。治疗组症状缓解、用药方便程度、治疗接受度用药期间感受良好评分均高于对照组,差异有统计学意义(P<0.05)。治疗组复发率为4.00%,低于对照组的16.00%,差异有统计学意义(P<0.05)。结论采用枸地氯雷他定联合西咪替丁治疗变态反应性皮肤病可有效降低患者不良反应发生率、复发率,提高临床疗效。
Objective To analyze the efficacy of loratadine combined with cimetidine in the treatment of allergic skin diseases.Methods A total of 100 patients with allergic skin diseases admitted to our hospital from July 2019 to June 2020 were selected as the research subjects,and they were divided into treatment group and control group according to the lottery method,with 50 cases in each group.The control group was treated with loratadine,and the treatment group was treated with cimetidine on the basis of the control group.The clinical efficacy,the level of inflammatory factors,chemokines and immune function molecules,the occurrence of adverse reactions,the efficacy sensitivity score and the recurrence were compared between the two groups.Results The total effective rate of the treatment group was 94.00%,which was higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the serum levels of interleukin-23(IL-23),interleukin-33(IL-33),and lung activation regulates chemokine/chemokine ligand-18(PARC/CCL-18)in the treatment group which were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of CD4^(+)and CD4^(+)/CD8^(+)were higher than those in the control group,and level of CD8^(+)was lower than that in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the treatment group was 4.00%,which was lower than 18.00%in the control group,and the difference was statistically significant(P<0.05).The treatment group had higher scores of symptom relief,medication convenience,and treatment acceptance,and the scores of feeling good during medication were higher than those in the control group(P<0.05).The recurrence rate in the treatment group was 4.00%,which was lower than 16.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion The treatment of allergic skin diseases with loratadine combined with cimetidine can
作者
沈菲
王玉琴
张程
SHEN Fei;WANG Yuqin;ZHANG Cheng(Department of skin of Kunshan Second People's Hospital,Kunshan,Jiangsu,215300,China)
出处
《当代医学》
2022年第28期32-35,共4页
Contemporary Medicine
