摘要
目的 探析自拟润肤祛风汤联合枸地氯雷他定治疗慢性湿疹的疗效。方法 选择2019年1月—2021年1月本院诊治的78例慢性湿疹患者作为研究对象,采用随机数字表法分为对照组和观察组两组,每组各39例。对照组给予枸地氯雷他定片,观察组在对照组基础上联合应用自拟润肤祛风汤,两组均连续治疗4周。对比两组治疗前、治疗4周后临床症状积分[湿疹面积及严重程度指数(EASI)]、相关细胞因子指标[白细胞介素-4(IL-4)、干扰素γ(INF-γ)、嗜酸性粒细胞计数(EOS)计数]、治疗有效性、治疗2个月后随访疾病复发率。结果 观察组慢性湿疹患者治疗有效率(97.44%)明显高于对照组(82.05%),差异有统计学意义(P<0.05)。治疗前两组患者EASI积分比较,差异无统计学意义(P>0.05);治疗后两组EASI积分均明显降低,且观察组下降幅度明显大于对照组,差异有统计学意义(P<0.05)。治疗前两组患者IL-4、INF-γ、EOS水平比较,差异无统计学意义(P>0.05);治疗后两组IL-4、EOS水平均明显降低,INF-γ水平明显升高,且观察组改善幅度明显大于对照组,差异有统计学意义(P<0.05)。随访2个月,观察组疾病复发率为2.63%(1/38),明显低于对照组18.75%(6/32),差异有统计学意义(P<0.05)。结论 自拟润肤祛风汤联合枸地氯雷他定治疗慢性湿疹临床效果显著,可有效减少湿疹面积,改善病情及IL-4、INF-γ、EOS水平,降低疾病复发率,值得临床推广。
Objective To explore the curative effect of self-made skin-moistening qufeng decoction combined with desloratadine citrate disodium tablets in the treatment of chronic eczema.Methods 78 patients suffered with chronic eczema those were treated in our hospital from January 2019 to January 2021 were enrolled as study objects, and according to the random number table method they were randomly divided into two groups, with 39 cases in each group. The control group was given desloratadine citrate disodium tablets, while the observation group was combined with self-made skin-moistening qufeng decoction on the basis of the control group. Both groups were treated continuously for 4 weeks. Clinical symptom score(eczema area and severity index, EASI), related cytokine indexes(interleukin-4(IL-4), interferon γ(INF-γ), eosinophil count(EOS) before and after treatment for 4 weeks, treatment effectiveness, and follow-up disease recurrence rate after 2 months of treatment were compared between the two groups.Results The effective rate of patients with chronic eczema in observation group(97.44%) was significantly higher than that in control group(82.05%)(P<0.05). There was no significant difference in EASI scores between the two groups before treatment(P>0.05). After treatment, the EASI scores in both groups decreased significantly, and the decrease in the observation group was significantly greater than that in the control group(P<0.05). There were no significant difference in IL-4, INF-γ and EOS between the two groups before treatment(P>0.05). After treatment, IL-4 and EOS in both groups decreased significantly, while INF-γ increased significantly, and the improvement in the observation group was significantly greater than that in the control group(P<0.05). Follow-up for 2 months, the recurrence rate of patients with chronic eczema in the observation group was 2.63%(1/38), which was significantly lower than 18.75%(6/32) in the control group(χ~2=5.0146, P<0.05).Conclusions The combination of self-made runfu qufeng decoction
作者
林论琼
何丽春
庄运平
刘美如
徐冬梅
Lin Lunqiong;He Lichun;Zhuang Yunping;Liu Meiru;Xu Dongmei(Department of dermatology,Huidong people's hospital,Huizhou,Guangdong,516300,China)
出处
《齐齐哈尔医学院学报》
2022年第12期1158-1161,共4页
Journal of Qiqihar Medical University
关键词
慢性湿疹
自拟润肤祛风汤
枸地氯雷他定
疗效
Chronic eczema
Self-made moisturizing qufeng decoction
Desloratadine citrate disodium tablets
Therapeutic effect
