摘要
目的探讨阿立哌唑与奥氮平治疗精神分裂症患者的临床疗效及对糖脂代谢的影响。方法选取2019年1—12月本院收治的160例精神分裂症患者作为研究对象,按照随机数字表法分为对照组和观察组,每组80例。对照组采用奥氮平治疗,观察组采用阿立哌唑治疗,比较两组血脂代谢指标[低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、总胆固醇(TC)]、血糖水平[餐后2 h血糖(2 h PG)、空腹血糖(FBG)]、阳性和阴性精神症状评定量表(PANSS)评分、临床疗效及不良反应发生情况。结果观察组治疗前后LDL-C、HDL-C、TG、TC水平比较差异无统计学意义;治疗后,对照组LDL-C、TG、TC水平均高于治疗前,HDL-C水平低于治疗前,而观察组LDL-C、TG、TC水平均低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05)。观察组治疗前后2 h PG、FBG水平比较差异无统计学意义;治疗后,对照组2 h PG、FBG水平均高于治疗前,而观察组2 h PG、FBG水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组病理症状评分、阴性症状评分、阳性症状评分均低于治疗前,差异有统计学意义(P<0.05);治疗后,两组病理症状评分、阴性症状评分、阳性症状评分比较差异无统计学意义。两组治疗总有效率比较差异无统计学意义。两组不良反应发生率比较差异无统计学意义。结论阿立哌唑与奥氮平治疗精神分裂症均具有较高的临床疗效及安全性,但奥氮平更易影响糖脂代谢指标。
Objective To explore the clinical efficacy of aripiprazole and olanzapine in the treatment of schizophrenia and its influence on glucose and lipid metabolism.Methods 160 patients with schizophrenic admitted to our hospital from January to December 2019 were selected as the research subjects,and they were divided into the control and the observation group according to the random number table method,with 80 cases in each group.The control group was treated with olanzapine,while the observation group was treated with aripiprazole,the indexes of blood lipid metabolism(low-density lipoprotein cholesterol[LDL-C],high-density lipoprotein cholesterol[HDL-C],triglyceride[TG],total cholesterol[TC]),blood glucose level(2 h postprandial blood glucose[2 h PG],fasting blood glucose[FBG]),positive and negative syndrome scale(PANSS)score,clinical efficacy and adverse reactions were compared between the two groups.Results There was no significant difference in the levels of LDL-C,HDL-C,TG and TC in the observation group before and after treatment;after treatment,the levels of LDL-C,TG and TC in the control group were higher than those before treatment,and the levels of HDL-C were lower than that before treatment,however,the levels of LDL-C,TG and TC in the observation group were lower than those in the control group,while the levels of HDL-C were higher than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the levels of 2 h PG and FBG in the observation group before and after treatment;after treatment,the levels of 2 h PG and FBG in the control group were higher than those before treatment,however,the observation group were lower than the control group,the differences were statistically significant(P<0.05).After treatment,the pathological symptom scores,negative symptom scores and positive symptom scores of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05);there was no significant difference in path
作者
姜秋波
徐伟平
JIANG Qiubo;XU Weiping(Yantai Laizhou Rongjun Hospital,Yantai,Shandong,261400,China)
出处
《当代医学》
2022年第27期8-11,共4页
Contemporary Medicine
关键词
阿立哌唑
奥氮平
精神分裂症
糖脂代谢
Aripiprazole
Olanzapine
Schizophrenia
Glucose and lipid metabolism
