摘要
近年来,我国抑郁症患病率不断攀升,抑郁症的防治工作已提升到国家战略层面。建立多中心、标准化的大规模抑郁症前瞻性研究队列可全面了解抑郁症的发作轨迹以及不同干预模式下的疾病转归,开发可用于指导临床实践的客观指标体系,为此我国启动了科技创新2030——抑郁症的前瞻性临床队列研究。为促进研究项目的高质量完成,本文从团队构建和人员职责、研究对象、临床数据、多维度数据、生物样本、随访、数据管理以及综合质量控制措施等多个方面对研究开展过程的风险点与研究关键点进行梳理,对队列研究质量控制措施进行总结。
In recent years,the incidence of depression has been continuously increasing in China.The prevention and treatment of depression has been elevated to the national strategic level.Establishing a multicenter and standardized large-scale prospective cohort study for depression can provide a comprehensively understanding of the pathogenesis and the disease outcomes under different intervention modes,and develop objective indicators system that can guide clinical practice.Therefore,the scientific and technological innovation 2030-prospective clinical cohort study of depression has launched,which is of great significance to the precision medicine research of depression in China.The authors combed the risks and research key points in the research and summarized the quality control measures of the cohort study from the aspects of team construction and personnel responsibilities,research objects,clinical data,multi-dimensional data,biological samples,follow-up,data management,and comprehensive quality control measures.
作者
伦碧汀
徐倩
孟佳雪
苑杰
汪海波
Xu Qian;Meng Jiaxue;Yuan Jie;Wang Haibo(Peking University Clinical Research Institute,Peking University First Hospital,Epidemiological Key Laboratory of Major Diseases of the Ministry of Education,Peking University,Beijing 100191,China)
出处
《神经疾病与精神卫生》
2023年第6期381-385,共5页
Journal of Neuroscience and Mental Health
基金
科技部科技创新2030(2021ZD0200603)。
关键词
抑郁症
队列研究
精准医学
质量控制
Depressive disorder
Cohort study
Precision medicine
Quality control
