摘要
目的探讨盐酸米诺环素辅助治疗中重度牙周炎的临床疗效。方法23例中重度牙周炎患者,采用分口设计方案,按照随机原则选择患者的一侧患牙为实验组,另一侧患牙为对照组,每侧选择2颗磨牙为受试牙,每组46颗。所有患者行超声龈上洁治与口腔卫生指导,1周后复诊,以此为基线进行牙周检查。检查完毕后,对照组行超声龈下刮治术和手工根面平整术,实验组在对照组基础上给予盐酸米诺环素软膏治疗。比较两组基线时及治疗后的牙周临床指标[探诊深度(PD)、临床附着丧失(CAL)、出血指数(BI)评分]、临床疗效。结果治疗后,两组PD、CAL、BI评分均较基线时改善,且实验组PD(3.95±0.30)mm小于对照组的(4.43±0.34)mm,CAL(3.41±0.16)mm少于对照组的(3.91±0.29)mm,BI评分(2.38±0.63)分低于对照组的(2.79±0.47)分,差异有统计学意义(P<0.05)。实验组治疗的总有效率为91.30%,高于对照组的73.91%,差异有统计学意义(P<0.05)。结论盐酸米诺环素辅助超声龈下刮治术和手工根面平整术可以提高治疗中重度牙周炎的效果。
Objective To discuss the clinical efficacy of minocycline hydrochloride in the adjuvant treatment of moderate and severe periodontitis.Methods 23 patients with moderate to severe periodontitis were treated with a split-mouth design scheme,in which one side of the patient's affected teeth was selected as the experimental group and the other side as the control group according to the randomization principle,and 2 molars were selected as the subject teeth on each side,with 46 teeth in each group.All patients received ultrasonic supragingival cleaning and oral hygiene guidance.The periodontal examination was performed as a baseline after 1 week of follow-up.After the examination,the control group received ultrasonic subgingival scaling and manual root planning,and the experimental group was treated with minocycline hydrochloride ointment on the basis of the control group.The periodontal clinical indicators[probing depth(PD),clinical attachment loss(CAL),bleeding index(BI)score]at baseline and after treatment and clinical efficacy of the two groups were compared.Results After treatment,PD,CAL and BI score in the two groups were all improved compared with those at baseline;PD of(3.95±0.30)mm in the experimental group was less than that of(4.43±0.34)mm in the control group;CAL of(3.41±0.16)mm in the experimental group was lower than that of(3.91±0.29)mm in the control group;BI score of(2.38±0.63)points in the experimental group was lower than that of(2.79±0.47)points in the control group;the differences were statistically significant(P<0.05).The total effective rate of the experimental group was 91.30%,which was higher than that of 73.91%of the control group,and the difference was statistically significant(P<0.05).Conclusion Minocycline hydrochloride assisted ultrasonic subgingival scaling and manual root planing can improve the effect of moderate and severe periodontitis.
作者
董小倩
仝泰瑞
王海芹
郭鲁燕
李文璐
DONG Xiao-qian;TONG Tai-rui;WANG Hai-qin(Department of Stomatology,Heze Municipal Hospital,Heze 274000,China)
出处
《中国实用医药》
2023年第11期127-129,共3页
China Practical Medicine
关键词
盐酸米诺环素
牙周炎
龈下刮治术
根面平整术
Minocycline hydrochloride
Periodontitis
Subgingival scaling
Root planing
