摘要
目的 探讨经尿道膀胱肿瘤电切术(TURBT)术后即刻吉西他滨灌注化疗在非肌层浸润性膀胱癌(NMIBC)患者中的应用效果.方法 根据治疗方法的不同将120例NMIBC患者分为观察组和对照组,每组60例,对照组患者给予TURBT治疗,观察组患者给予TURBT术后即刻吉西他滨灌注化疗.比较两组患者的临床疗效、血清肿瘤标志物[血管内皮生长因子(VEGF)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)、胰岛素样生长因子-1(IGF-1)、膀胱癌特异性核基质蛋白-1(BLCA-1)]水平、复发情况和不良反应发生情况.结果 观察组患者的临床总有效率为91.67%,明显高于对照组患者的63.33%,差异有统计学意义(P﹤0.01).治疗后,两组患者血清VEGF、CYFRA21-1、IGF-1、BLCA-1水平均低于本组治疗前,且观察组患者血清VEGF、CYFRA21-1、IGF-1、BLCA-1水平均低于对照组,差异均有统计学意义(P﹤0.05).随访1年,观察组患者的复发率为1.67%,明显低于对照组患者的16.67%,差异有统计学意义(P﹤0.01).观察组患者的不良反应总发生率为13.33%,与对照组患者的8.33%比较,差异无统计学意义(P﹥0.05).结论 NMIBC患者TURBT术后即刻给予吉西他滨灌注化疗,可有效延缓疾病进展,延长生存期,降低复发率和血清肿瘤标志物水平,且安全性较高.
Objective To investigate the effect of immediate gemcitabine infusion chemotherapy after transurethral resection of bladder tumor(TURBT)in patients with non-muscle invasive bladder cancer(NMIBC).Method According to different treatment methods,120 NMIBC patients were divided into observation group and control group,with 60 patients in each group.The control group received TURBT treatment,while the observation group received immediate gemcitabine infusion chemotherapy after TURBT.Compared the clinical efficacy,serum tumor markers[vascular endothelial growth factor(VEGF),cyto-keratin 19 fragment antigen 21-1(CYFRA21-1),insulin-like growth factor-1(IGF-1),bladder cancer specific nuclear matrix protein-1(BLCA-1)],the incidence of recurrence and adverse reactions between two groups.Result The total clinical effective rate of the observation group was 91.67%,which was higher than 63.33%of the control group,and the difference was statistically significant(P<0.01).After treatment,the levels of VEGF,CYFRA21-1,IGF-1,and BLCA-1 in both groups were lower than those before the treatment,and the levels of VEGF,CYFRA21-1,IGF-1,and BLCA-1 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After one-year follow-up,the recurrence rate of the observation group was 1.67%,significantly lower than 16.67%of the control group,and the difference was statistically significant(P<0.01).The total incidence of adverse reactions in the observation group was 13.33%,which was not statistically significant compared to 8.33%in the control group(P>0.05).Conclusion Immediate gemcitabine infusion chemotherapy after TURBT in NMIBC patients can effectively delay disease progression,prolong survival,reduce recurrence rate,and lower serum tumor marker levels,with high safety.
作者
王亚辉
兀尧
燕群峰
杜昌国
WANG Yahui;WU Yao;YAN Qunfeng;DU Changguo(Department of Urology Surgery,the First People’sHospital of Xianyang,Xianyang 712000,Shaanxi,China)
出处
《癌症进展》
2023年第9期997-1000,共4页
Oncology Progress
关键词
非肌层浸润性膀胱癌
经尿道膀胱肿瘤电切术
吉西他滨
灌注化疗
non-muscle invasive bladder cancer
transurethral resection of bladder tumor
gemcitabine
infusion chemotherapy
