摘要
目的总结Top1抑制剂与Tdp1抑制剂整体概况,探究其发展趋势,为后续研究提供参考。方法运用CiteSpace 5.7.R5软件对2012年1月—2022年4月收录在Web of Science(WOS)核心合集数据库中Top1抑制剂与Tdp1抑制剂的相关文献进行作者、机构、被引期刊、国家、关键词可视化分析。结果共纳入有效文献1186篇,Yves Pommier为发文量最高的作者;美国国家癌症研究所为发文量最高的机构,机构之间具有一定的联系但是合作较为分散,美国研究该领域最全面;Journal of Biological Chemistry为被引率最高的期刊;关键词细胞凋亡、抗肿瘤、抑制剂出现频率高,Top1抑制剂与Tdp1抑制剂研究方向集中于Top1抑制剂、Tdp1抑制剂的发现、合成以及抗肿瘤机制。结论开发更多新型Top1抑制剂、Tdp1抑制剂甚至Top1-Tdp1双靶点抑制剂以进一步提高药物抗肿瘤活性将成为未来研究趋势。
Objective To overall overview Top1 inhibitor and Tdp1 inhibitors and their development to provide reference for future studies.Methods CiteSpace 5.7.R5 software was used to visualize and analyze the authors,institutions,cited journals,countries,and keywords of Top1 inhibitor and Tdp1 inhibitor-related literatures in the Web of Science(WOS)core collection database from January 2012 to April 2022.Results Totally 1186 papers were included.Yves Pommier was author with the most publications;the National Cancer Institute was the institution with most publications.Some connections and collaborations existed between institutions.The most comprehensive research in this field was in the US;Journal of Biological Chemistry was the most cited journal;keywords apoptosis,anticancer,and inhibitors appeared most frequently;Top1 inhibitor and Tdp1 inhibitor research focused most on the discovery,synthesis,and anti-tumor mechanisms.Conclusion Discovery of more novel Top1 inhibitor or Tdp1 inhibitors or even Top1-Tdp1 dual-target inhibitors in further enhance the anti-tumor activity of the drugs is a hot topic for future research.
作者
刘晓晨
农雅琴
张洪茂
高梅菲
徐浩
潘小芳
米文静
陈睿
霍丽妮
LIU Xiao-chen;NONG Ya-qin;ZHANG Hong-mao;GAO Mei-fei;XU Hao;PAN Xiao-fang;MI Wen-jing;CHEN Rui;HUO Li-ni(School of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200;Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine,Nanning 530222)
出处
《中南药学》
2023年第6期1674-1683,共10页
Central South Pharmacy
基金
国家自然科学基金项目(No.22067001)
广西壮瑶药重点实验室(桂科基字[2014]32号)
壮瑶药协同创新中心(桂教科研[2013]20号)
广西壮族自治区民族药资源与应用工程研究中心(桂发改高技函[2020]2605号)
广西研究生联合培养基地(桂学位[2021]6号)。
