摘要
目的:观察瓜蒌承气汤加减联合常规西药治疗急性脑出血患者的效果。方法:选取2020年2月至2022年4月该院收治的80例急性脑出血患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各40例。对照组采用常规西药治疗,观察组在对照组基础上联合瓜蒌承气汤加减治疗,比较两组治疗前后疾病相关指标[脑钠肽(BNP)、C反应蛋白(CRP)]水平、血液流变学指标水平、神经功能缺损程度[脑卒中患者临床神经功能缺损程度评分标准(MESSS)]评分、中医证候积分、临床疗效和不良反应发生率。结果:治疗后,两组BNP、CPR水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组全血低切黏度、全血高切黏度、血浆黏度均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组MESSS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组肢体不遂、口舌歪斜、头晕、言语不利等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为92.50%(37/40),高于对照组的75.00%(30/40),差异有统计学意义(P<0.05);两组治疗期间均未见明显不良反应。结论:瓜蒌承气汤加减联合常规西药治疗急性脑出血患者可提高治疗总有效率,降低疾病相关指标水平、血液流变学指标水平和中医证候积分,其效果优于单纯常规西药治疗。
Objective:To observe effects of Gualou Chengqi decoction combined with conventional Western medicine in treatment of patients with acute cerebral hemorrhage.Methods:A prospective study was conducted on 80 patients with acute cerebral hemorrhage admitted to this hospital from February 2020 to April 2022.They were divided into control group and observation group according to the random number table method,40 cases in each.The control group was treated with conventional Western medicine,while the observation group was treated with Gualou Chengqi decoction on the basis of that of the control group.The levels of disease-related indexes[brain natriuretic peptide(BNP),C-reactive protein(CRP)],the hemorheology index levels,the neurological deficit degree[clinical neurological deficit score standard(MESSS)],the TCM syndrome score,the clinical efficacy,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the levels of BNP,CPR and other disease-related indexes in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of hemorheology indexes such as whole blood low shear viscosity,whole blood high shear viscosity and plasma viscosity in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The MESSS scores of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).The scores of TCM symptoms such as limb dysfunction,tongue deviation,dizziness and speech impairment in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically si
作者
王晓林
WANG Xiaolin(Emergency Department of Kaifeng Second Hospital of Traditional Chinese Medicine,Kaifeng 475000 Henan,China)
出处
《中国民康医学》
2023年第10期106-108,112,共4页
Medical Journal of Chinese People’s Health
关键词
瓜蒌承气汤
加减
急性脑出血
血液流变学
中医证候积分
Gualou Chengqi decoction
Addition and subtraction treatment
Acute cerebral hemorrhage
Hemorheology
TCM symptom score
