盐酸米诺环素软膏治疗急性智齿冠周炎患者的效果

Effects of Minocycline hydrochloride ointment in treatment of patients with acute wisdom teeth pericoronitis

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摘要目的:观察盐酸米诺环素软膏治疗急性智齿冠周炎患者的效果。方法:选取2020年2月至2022年2月该院收治的78例急性智齿冠周炎患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各39例。对照组予以碘甘油治疗,观察组予以盐酸米诺环素软膏治疗。比较两组疗效、症状缓解时间(疼痛、肿胀、张口受限缓解时间)、牙周指标[牙周袋深度(PD)、附着丧失(AL)、菌斑指数(PLI)]水平、龈沟液炎性因子[白细胞介素-8(IL-8)、IL-1β、IL-10、前列腺素E2(PGE2)]水平、冠周袋内微生物(中间普氏菌、消化链球菌、牙龈卟啉单胞菌)水平和不良反应发生率。结果:观察组治疗总有效率为92.31%,明显高于对照组的74.36%,差异有统计学意义(P<0.05);观察组疼痛、肿胀、张口受限缓解时间均短于对照组,差异有统计学意义(P<0.05);治疗3 d后,两组PD、AL、PLI、IL-1β、IL-8、PGE2水平及中间普氏菌、消化链球菌、牙龈卟啉单胞菌数量均低于治疗前,且观察组低于对照组,两组IL-10水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:盐酸米诺环素软膏治疗急性智齿冠周炎可提高治疗总有效率,改善龈沟液炎性因子水平,缩短症状缓解时间,降低牙周指标水平和冠周袋内微生物数量,优于碘甘油治疗效果。 Objective:To observe effects of Minocycline hydrochloride ointment in treatment of patients with acute wisdom teeth pericoronitis.Methods:A prospective study was conducted on 78 patients with acute wisdom teeth pericoronitis admitted to this hospital from February 2020 to February 2022.They were divided into control group and observation group according to the random number table method,39 cases in each group.The control group was treated with Iodine glycerin,while the observation group was treated with Minocycline hydrochloride ointment.The efficacy,the symptom remission time(pain,swelling,and mouth opening limitation relief time),the periodontal index levels[periodontal pocket depth(PD),attachment loss(AL),plaque index(PLI)],the gingival crevicular fluid inflammatory factor levels[interleukin-8(IL-8),IL-1β,IL-10,prostaglandin E2(PGE2)],the microorganism levels in the pericoronal pocket(Prevotella intermedia,Peptostreptococcus,Porphyromonas gingivalis),and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 92.31%,which was significantly higher than 74.36%in the control group,and the difference was statistically significant(P<0.05).The pain,the swelling and the mouth opening limitation relief time in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).After 3 days of treatment,the levels of PD,AL,PLI,IL-1β,IL-8,PGE2,Prevotella intermedia,Peptostreptococcus and Porphyromonas gingivalis in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the levels of IL-10 in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Concl

作者韩婷婷 HAN Tingting(Department of Stomatology of Henan No.3 Provincial People's Hospital,Zhengzhou 450002 Henan,China)

机构地区河南省直第三人民医院口腔科

出处《中国民康医学》 2023年第10期89-92,共4页 Medical Journal of Chinese People’s Health

关键词急性智齿冠周炎碘甘油盐酸米诺环素软膏炎性因子牙周指标微生物不良反应 Acute wisdom teeth pericoronitis Iodine glycerin Minocycline hydrochloride ointment Inflammatory factor Periodontal index Microorganisms Adverse reaction

分类号 R782.3 [医药卫生—口腔医学]