摘要
目的研究维生素E联合小剂量阿司匹林、钙剂、叶酸治疗对子痫前期的预防作用及对母胎结局的影响。方法前瞻性选取2018年1月至2022年1月合肥市第一人民医院收治的150例子痫前期高危孕妇,按照随机数字表法分为对照组和研究组,各75例。研究组于对照组基础上联合给予维生素E处理,对照组行小剂量阿司匹林、钙剂、叶酸干预,持续至孕36周。比较两组孕妇的子痫前期发生率、治疗前后凝血四项[纤维蛋白原(Fib)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)]、子宫动脉血流参数[阻力指数(RI)、收缩期峰值/舒张末期流速(S/D)、搏动指数(PI)]、母胎结局和新生儿出生指标。结果研究组孕妇子痫前期发生率为9.33%(7/75),明显低于对照组[22.67%(17/75)],差异有统计学意义(P<0.05)。两组孕妇治疗后Fib均明显低于治疗前,APTT、TT、PT均明显高于治疗前,且研究组Fib为(3.92±0.33)g/L,明显低于对照组[(4.15±0.35)g/L],APTT、TT、PT为(27.36±1.85)、(13.72±0.77)、(10.13±0.60)s,均明显高于对照组[(26.28±2.01)、(13.38±0.79)、(9.73±0.64)s],差异均有统计学意义(P<0.05)。两组孕妇治疗后子宫动脉RI、S/D、PI均明显低于治疗前,且研究组为0.37±0.06、1.73±0.45、0.62±0.17,明显低于对照组(0.42±0.08、1.91±0.48、0.70±0.19),差异均有统计学意义(P<0.05)。研究组胎儿生长受限、剖宫产、早产、胎盘早剥发生率为5.33%、13.33%、17.33%、6.67%,均明显低于对照组(16.00%、28.00%、34.67%、18.67%),差异有统计学意义(P<0.05)。研究组新生儿出生孕周、体重、1 min Apgar评分为(37.97±1.06)周、(2.94±0.91)kg、(9.53±0.74)分,均明显高于对照组[(37.22±1.01)周、(2.61±0.85)kg、(9.29±0.65)分],差异均有统计学意义(P<0.05)。结论维生素E联合小剂量阿司匹林、钙剂、叶酸能更有效改善子痫前期高危孕妇的凝血功能及子宫动脉血流动力学,在预防�
Objective To study the effect of vitamin E combined with low-dose aspirin,calcium and folic acid therapy on the prevention of preeclampsia,on maternal-fetal outcome.Methods A total of 150 pregnant women with high risk of preeclampsia in The First People's Hospital of Hefei from January 2018 to January 2022 were selected and randomly divided into control group and study group,with 75 cases in each group.The control group received low-dose aspirin,calcium,and folic acid intervention,and the study group was combined with vitamin E on the basis of the control group,which lasted until 36 weeks of pregnancy.The incidence of preeclampsia,four coagulation items[fibrinogen(Fib),activated partial thromboplastin time(APTT),thrombin time(TT),prothrombin time(PT)].uterine artery blood flow parameters[resistance index(RI),peak systolic/end-diastolic velocity(S/D),pulsatility index(PI)],maternal and fetal outcomes,and neonatal birth indicators.Results The incidence of preeclampsia in the study group was 9.33%(7/75),which was lower than that in the control group[22.67%(17/75)],the difference was statistically significant(P<0.05).After treatment,the Fib of pregnant women in the two groups were significantly lower than those before treatment,and the APTT,TT and PT were significantly higher than that before treatment,and the Fib in the study group was(3.92±0.33)g/L,which was significantly lower than that in the control group[(4.15±0.35)g/L],and the APTT,TT and PT were(27.36±1.85),(13.72±0.77),(10.13±0.60)s,which were significantly higher than those in the control group[(26.28±2.01),(13.38±0.79),(9.73±0.64)s],the differences were statistically significant(P<0.05).After treatment,the RI,S/D and PI of uterine artery in both groups were lower than those before treatment,and the research group was 0.37±0.06,1.73±0.45,0.62±0.17,which was lower than that in the control group(0.42±0.08,1.91±0.48,0.70±0.19),the difference was statistically significant(P<0.05).The incidence rates of fetal growth restriction,cesarean section,pre
作者
许荣
裴芳
洪琼
XU Rong;PEI Fang;HONG Qiong(Department of Obstetrics and Gynecology,The First People's Hospital of Hefei,Hefei Anhui 230031,China)
出处
《临床和实验医学杂志》
2023年第10期1076-1080,共5页
Journal of Clinical and Experimental Medicine
基金
2020年度安徽高校自然科学研究项目(编号:KJ2020A0204)。
关键词
子痫前期
维生素E
阿司匹林
预防
母胎结局
Preeclampsia
High risk
Aspirin
Vitamin E
Prevention
Maternal-fetal outcome
