摘要
皮肤溃疡是糖尿病最常见的并发症,糖尿病溃疡患者死亡率远高于无溃疡糖尿病患者。近年来,中草药因具有多成分、多靶点、多通路协同的治疗效应而受到广泛关注。临床实践证明,中草药能有效促进糖尿病创面愈合,并展现出良好的安全性。为系统评价中草药对糖尿病溃疡的治疗效应,笔者通过检索文献,回顾和总结了15种中草药提取物促进糖尿病创面愈合的作用机制,并基于传统中医药理论进行分类讨论,以期为糖尿病溃疡的精准治疗及新药研发提供参考。
Skin ulcers are the most prevalent consequence of diabetes mellitus,and people with diabetic ulcers have a substantially greater death risk than those who do not have ulcers.Herbal medications have gained wide concern in recent years due to their multi-component,multi-target,and multi-pathway synergistic therapeutic effects.Clinical trials have demonstrated the safety and efficacy of herbal treatments in diabetic refractory ulcers.To systematically evaluate the healing effect of herbs on diabetic wounds,a literature search was conducted,the mechanism of action of 15 herbal extracts in promoting diabetic wound healing were reviewed,and the classification based on traditional Chinese medicine theory was discussed,which could provide a reference for the precise treatment and exploitation of herbal medicines for diabetic ulcers.
作者
陆涵之
王怡
郭冬婕
郭婉军
朱建勇
李福伦
LU Hanzhi;WANG Yi;GUO Dongjie;GUO Wanjun;ZHU Jianyong;LI Fulun(Department of Dermatology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Department of Pharmacy Research,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
出处
《药学实践与服务》
CAS
2023年第6期335-340,357,共7页
Journal of Pharmaceutical Practice and Service
基金
国家自然科学基金(82074428)
上海市科学技术委员会项目(20XD1423600,20DZ2301900)
上海市卫生健康委员会中医药科研项目创新团队类项目(2022CX011)
上海市科学技术委员会启明星计划扬帆专项(22YF1449700)
国家中医药管理局皮肤病中医特色疗法循证能力建设项目
国家中医药管理局“青年岐黄学者”项目。
关键词
中草药
提取物
糖尿病溃疡
作用机制
Chinese herbal medicine
extracts
diabetic ulcers
mechanism of action
