摘要
骨质疏松是以骨量低下,骨组织微结构恶化为特点的骨骼退化型疾病,分为原发性和继发性,随着人口老龄化,骨质疏松发病率逐年升高,其预防和治疗也显得尤为重要。近年来,越来越多的学者研究发现原发性醛固酮增多症患者与普通人群相比更易发生骨量低下、骨折疏松甚至脆性骨折,同时往往伴随有较高的甲状旁腺素水平,因此提出了继发性甲状旁腺功能亢进假说。有证据表明醛固酮与甲状旁腺素相互影响,二者共同作用可增加骨质疏松的风险,该文将从二者的关系及其对骨代谢的影响作用机制进行综述。
Osteoporosis is a degenerative bone disease characterized by low bone mass and deterioration of bone microstructure,which can be divided into primary and secondary diseases.With the aging of the population,the incidence of osteoporosis increases year by year.The prevention and treatment of osteoporosis are particularly important.In recent years,more and more scholars have found that patients with primary aldosteronism are more likely to suffer from low bone mass,loose fracture,and even brittleness fracture compared with the general population.These patients are often accompanied with higher levels of parathyroid hormone.Therefore,the hypothesis of secondary hyperparathyroidism has been proposed.There is evidence that aldosterone and parathyroid hormone interact with each other,and their combined action increases the risk of osteoporosis.This paper reviews the relationship between the two and the mechanism of their effects on bone metabolism.
作者
夏珊
曹旭
XIA Shan;CAO Xu(College of Clinical Medicine,Zunyi Medical University,Zunyi 563000,China;Department of Endocrinology,Sichuan Academy of Medical Sciences,Sichuan Provincial People’s Hospital,Chengdu 610072,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2023年第6期916-921,共6页
Chinese Journal of Osteoporosis
基金
四川省科技计划项目(2020YFS0422)。
关键词
醛固酮
甲状旁腺素
骨代谢
骨质疏松症
aldosterone
parathyroid hormone
bone metabolism
osteoporosis
