摘要
目的分析黄山市8726名孕妇孕中期血清学筛查结果。方法收集8726名孕妇孕中期血清学筛查结果,根据筛查结果分为高风险组、临界风险组和低风险组。通过定量测定孕妇血液中与妊娠有关的生化标记物[甲胎蛋白(AFP)、总β人绒毛膜促性腺激素(β-HCG)、游离雌三醇(uE3)]浓度,结合孕妇年龄、体质量、孕周等因素对胎儿患有21三体综合征(DS)、18三体综合征(ES)和开放性神经管缺陷(ONTD)的风险进行综合评估。结果8726名孕妇孕中期血清学筛查出3种疾病高风险孕妇575名,高风险检出率6.59%(575/8726),其中DS高风险224名,检出率2.57%(224/8726);ES高风险9名,检出率0.10%(9/8726);ONTD高风险342名,检出率3.92%(342/8726)。575名筛查高风险孕妇中,ONTD高风险占比最高,为59.48%(342/575),DS占比38.96%(224/575),ES占比1.57%(9/575)。不同年龄孕妇血清学筛查高风险检出率比较,差异有统计学意义(P<0.05)。其中15~19岁年龄孕妇高风险检出率最高(10.59%),30~34岁年龄孕妇高风险检出率次之(7.97%)。不同孕周孕妇血清学筛查高风险检出率比较差异无统计学意义(P>0.05)。575名筛查出的高风险孕妇均选择进一步检查,包括羊水穿刺64名、先行无创产前筛查(NIPT)314名及单纯超声检查197名。随访结果,224例DS高风险孕妇中不良妊娠结局8名;9例ES高风险孕妇不良妊娠结局3名;342例ONTD高风险孕妇不良妊娠结局28名。结论孕中期血清学筛查对预防出生缺陷有重要作用,规范开展血清学筛查,可有效降低出生缺陷发生率。
Objective To analyze the serological screening results of 8726 pregnant women in Huangshan City during the second trimester.Methods The serological screening results of 8726 pregnant women during the second trimester were collected and divided into high-risk group,critical risk group and low risk group according to the screening results.The concentrations of biochemical markers related to pregnancy[alpha-fetoprotein(AFP),totalβhuman chorionic gonadotropin(β-HCG),free estriol(uE_(3))]in the blood of pregnant women were quantitatively determined.The risk of trisomy 21 syndrome(DS),Trisomy 18 syndrome(ES)and open neural tube defect(ONTD)was evaluated by taking into account maternal age,body weight,gestational age and other factors.Results Among the 8726 pregnant women,575 were found to be at high risk of 3 diseases during the second trimester serological screening,and the high risk detection rate was 6.59%(575/8726),among which 224 were at high risk of DS,and the detection rate was 2.57%(224/8726).9 patients were at high risk of ES,and the detection rate was 0.10%(9/8726).There were 342 patients with high risk of ONTD,and the detection rate was 3.92%(342/8726).Among 575 high-risk pregnant women,the high-risk ratio of ONTD was the highest 59.48%(342/575),DS was 38.96%(224/575)and ES was 1.57%(9/575).There were statistically significant differences in serological screening high risk detection rates among pregnant women of different ages(P<0.05).Pregnant women aged 15~19 years had the highest risk detection rate(10.59%),followed by pregnant women aged 30~34 years(7.97%).There was no significant difference in serological screening risk detection rate of pregnant women at different gestational weeks(P>0.05).All 575 high-risk pregnant women selected for further examination,including 64 amniocentesis,314 prior noninvasive prenatal screening(NIPT)and 197 ultrasound alone.The follow-up results showed that 8 of 224 high-risk pregnant women with DS had adverse pregnancy outcomes.3 of 9 high-risk ES pregnant women had adverse
作者
黄玲
卢惠兰
孟登弘
郦晓燕
黄燕
Huang Ling;Lu Huilan;Meng Denghong;Li Xiaoyan;Huang Yan(Department of Health Care,Huangshan Maternal and Child Health and Family Planning Service Center,Huangshan 245000,China)
出处
《实用妇科内分泌电子杂志》
2023年第4期36-39,共4页
Electronic Journal of Practical Gynecological Endocrinology
关键词
孕中期
血清学筛查
高风险
出生缺陷
Second trimester
Serological screening
High risk
Birth defect
