摘要
目的:探讨唐氏综合征(Down's syndrome,DS)产前血清学筛查的临床应用价值。方法:用全自动时间荧光免疫分辨仪对23921例妊娠14～21周的孕妇进行血清甲胎蛋白(AFP)、游离绒毛膜促性腺激素β亚基(Free-β-HCG)、游离雌三醇(uE3)检测,结合软件进行风险评估,对筛查阳性孕妇进行羊水细胞染色体检查以确诊。结果:23921例孕妇中,DS高风险1494例,其中1048例作了羊水细胞染色体核型分析。检出异常核型66例,异常率为6.30%。确诊21-三体11例,确诊阳性率为1.05%。非高龄孕妇胎儿的异常率(56/776,7.22%)明显高于高龄(≥35岁)孕妇胎儿的异常率(10/272,3.68%),P=0.04。结论:产前血清学筛查是预防唐氏综合征等染色体异常患儿出生的有效方法,同时结合其它检查方法可提高产前筛查效果。
Objective： To explore the clinical application value of prenatal serological screening for Down syndrome. Methods： The serum levels of alpha - fetoprotein （AFP） , fiee beta - human chorionic gonadotrophin （Free - 13 - HCG） and unconjugated estriol （uE3） of 23 921 pregnant women with 14 -21 gestational weeks were detected by automatic fluoroimmunoassay, chromosome examination of amniotie fluid cells was conducted on positive pregnant women. Results： Among 23 921 pregnant women, 1 494 pregnant women were found with high risk factors of Down syndrome, and 1 048 pregnant women received karyotype analysis of amniotic fluid cells. 66 pregnant women （6. 30% ） were found with abnormal karyotypes; 11 pregnant women （ 1.05% ） were diagnosed as 21 trisomy syndrome; the abnormal rate of fetus of pregnant women 〈 35 years （56/776, 7. 22%） was higher than that of pregnant women ≥ 35 years （ 10/272, 3.68%） （ P = 0. 04） . Conclusion ： Prenatal serological screening is an effective method to prevent the birth of infants with chromosome anomaly, and prenatal serological screening combined with other tests may promote screening effects.
出处
《中国妇幼保健》
CAS
北大核心
2010年第1期93-95,共3页
Maternal and Child Health Care of China
基金
国家自然科学基金资助〔35071867〕
关键词
唐氏综合征
产前诊断
血清学筛查
核型分析
Down syndrome
Prenatal diagnosis
Serological screening
Karyotype analysis
