摘要
目的 探讨唐氏综合征产前筛查的方法以及影响其风险值的主要因素 .方法 用全自动时间荧光免疫分辨仪对 1198例怀孕 9～ 2 0周妇女进行血清妊娠相关血浆蛋白A(PAPP -A)、甲胎蛋白 (AFP )、游离绒毛膜促性腺激素Β亚基 (FREEβ-HCG)检测 .结果 风险率 1:2 5 0以上的孕妇 12 2例 ,其中 4 4例抽羊水或脐血进行染色体检测 ,有 2例确诊为阳性 ,而暂无 1例假阴性 .结论 血清PAPP -A、AFP、FREEβ -HCG的检测可作为唐氏筛查的优选生化项目 ,其血清水平以及母亲年龄、孕周、体重等是影响其风险值的主要因素 .
Objective In order to study the method for screening Down's syndrome and assess interfering factor. Methods To determine the value of prenacy-associated plasma protein A (PAPP-A), free beta-human chorionic gonadotrophin (FREE β-HCG) and alpha-foetoprotein (AFP) in the serum of 1198 pregnant women at about 9th～20th weeks gestation with the auto time-resolved fluoroimmunoassay system. Results There were 122 women who had a fetus with risk of Down's syndrome above 1/250, among them, 44 pregnant women were done the pregnant diagnosis by amniocentesis and cordocentesis to check the chromosomal of the fetus.Two women had a fetus with Down's syndrome. Up to now, no trisomy 21 cases were missed by the screening method. Conclusions Serum measurements of PAPP-A, AFP and FREE β-HCG were the best choice method in screening Down's syndrome. The serum level of PAPP-A, AFP and FREE β-HCG in combination with pregnant women's age, weight and weeks of gestation were the main affected factors in assessing the risk.
出处
《现代临床医学生物工程学杂志》
2002年第4期259-260,共2页
Journal of Modern Clinical Medical Bioengineering
