摘要
目的:探讨妊娠期糖尿病(GDM)患者孕晚期凝血功能及纤溶系统指标及对妊娠结局影响。方法:回顾性收集2020年12月-2022年2月本院分娩的孕晚期孕妇临床资料170例,合并GDM为GDM组(n=85),无GDM者为对照组(n=85),检测凝血功能及纤溶系统指标,统计妊娠结局,分析凝血功能、纤溶系统指标与妊娠结局相关性。结果:GDM组血酶原时间(PT)(11.12±1.55 s)、活化部分凝血活酶时间(APTT)(25.64±2.97s)、纤维蛋白原(FIB)(4.29±0.81 g/L)低于对照组(14.56±2.87s、37.54±4.26s、3.09±0.34 g/L),纤维蛋白降解产物(FDP)(3.10±0.39 mg/L)、D二聚体(DD)(0.89±0.09 g/L)高于对照组(2.27±0.24 mg/L、0.67±0.07 g/L),不良妊娠结局发生率(41.2%)高于对照组(12.9%)(均P<0.05);logistic回归分析,PT≤10.8s、APTT≤25.3s、FIB≤4g/L、DD>0.91g/L、FDP 2.78mg/L、空腹血糖>7.0mmol/L是影响孕晚期GDM产妇不良妊娠结局的危险因素(P<0.05)。结论:孕晚期GDM患者凝血功能及纤溶系统指标均发生异常,不良妊娠结局升高,PT、APTT、FIB、DD、FDP、空腹血糖异常均是影响GDM孕妇不良妊娠结局的危险因素,提示临床予以检测干预,以改善妊娠结局。
Objective:To explore the indexes of coagulation function and fibrinolytic system of pregnant women with gestational diabetes mellitus(GDM)during the third trimester of pregnancy,and to study their influence on the adverse pregnancy outcomes of these women.Methods:The clinical data of 170pregnant women during the third trimester of pregnancy and who had delivered in hospital from December 2020to February 2022were analyzed retrospectively.These women were divided in observation group(85women with GDM)and in control group(85women without GDM).The coagulation function and fibrinolytic system indexes of the women in the two groups were detected.The pregnancy outcomes of the women in the two groups were counted.The correlation between the coagulation function and fibrinolytic system indexes of the women and their pregnancy outcomes was analyzed.Results:The prohemase time(PT)value(11.12±1.55s),the activated partial thrombin time(APTT)value(25.64±2.97s),and the fibrinogen(FIB)level(4.29±0.81g/L)of the women in the observation group were significantly lower than those(14.56±2.87s,37.54±4.26s,and 3.09±0.34g/L)of the women in the control group.The fibrin degradation products(FDP)value(3.10±0.39mg/L)and D dimer(DD)level(0.89±0.09g/L)of the women in the observation group were significantly higher than those(2.27±0.24mg/L and 0.67±0.07g/L)of the women in the control group.The incidence of adverse pregnancy outcomes(41.2%)of the women in the observation group was significantly higher than that(12.9%)of the women in the control group(all P<0.05).Logistic regression analysis showed that the PT≤10.8s,the APTT≤25.3s,the FIB level≤4g/L,the DD level>0.91g/L,the FDP level of 2.78mg/L,and the fasting blood glucose level>7.0mmol/L of the women with GDM during the third trimester of pregnancy were the risk factors of their adverse pregnancy outcomes(P<0.05).Conclusion:The coagulation function and fibrinolytic system indexes of the women with GDM during the third trimester of pregnancy are abnormally,and the adverse pregna
作者
陈勇
凌建
秦峰
杨琴
CHEN Yong;LING Jian;QIN Feng;YANG Qin(Mianyang People's Hospital,Mianyang,Sichuan Province,621000)
出处
《中国计划生育学杂志》
2023年第6期1445-1449,共5页
Chinese Journal of Family Planning
基金
四川省绵阳市卫健委科研基金资助项目(201846)。
关键词
妊娠期糖尿病
妊娠晚期
凝血功能
纤溶系统指标
不良妊娠结局
影响因素
Gestational diabetes mellitus
The third trimester of pregnancy
Coagulation function
Fibrinolysis system index
Adverse pregnancy outcomes
Influence factor
