摘要
目的探讨三拗汤辨证加减联合阿奇霉素治疗小儿支原体肺炎的临床观察。方法将2020年1月-2021年5月在该院儿科治疗的158例小儿支原体肺炎患儿随机分为两组,对照组使用常规西医治疗(阿奇霉素+孟鲁司特钠),在此基础上,观察组使用三拗汤辨证加减,对比两组的临床疗效、症状消失时间、TH1/TH2细胞因子水平变化、炎性因子水平变化、肺功能指标。结果观察组治疗有效率为96.20%(76/79),明显高于对照组的78.48%(62/79)(P<0.05);观察组咳嗽、发热、咯痰、喘促、肺部湿啰音等症状消失时间以及治疗时间明显短于对照组(P<0.05);观察组治疗后IL-2、INF-γ水平明显低于对照组,IL-4、IL-10水平明显高于对照组(P<0.05);观察组治疗后TNF-α、CRP、ESR水平明显低于对照组(P<0.05);观察组治疗后FVC、FEV1、MVV、FEV1/FVC明显高于对照组(P<0.05)。结论三拗汤辨证加减联合阿奇霉素治疗小儿支原体肺炎的临床疗效显著,能有效缩短病程,抑制炎性因子,调节机体免疫,促进肺功能的恢复,具有积极的临床意义。结论白术挥发油主要成分为苍术酮、β-桉油醇等半萜类化合物,具有显著抗癌性恶病质作用。
Objective To explore the clinical observation of the treatment of mycoplasma pneumonia in children with Modified San′ao Decoction(三拗汤辨证加减)according to syndrome differentiation combined with azithromycin.Methods A total of 158 cases of children with mycoplasma pneumonia treated in the hospital from January 2020 to may 2021 were randomly divided into two groups.The control group was treated with conventional Western medicine(azithromycin+montelukast).On this basis,the observation group was treated with Modified San′ao Decoction according to syndrome differentiation.The clinical efficacy,symptom disappearance time,Th1/Th2 cytokine level,inflammatory factor level,clinical symptoms and signs and lung function indexes were compared between the two groups.Results The effective rate of the observation group was 96.20%(76/79),which was significantly higher than 78.48%(62/79)of the control group(P<0.05).The disappearance time and treatment time of cough,fever,expectoration,shortness of breath and lung moist rales in the observation group were significantly shorter than those in the control group(P<0.05).The levels of interleukin(IL)-2 and interferon-γ(INF-γ)in the observation group after treatment were obviously than those of the control group and the levels of IL-4 and IL-10 in the treatment group were significantly higher than those in the control group(P<0.05).The levels of tumor necrosis factor-α(TNF-α),C-reaction protein(CRP)and erythrocyte sedimentation rate(ESR in the observation group after treatment were significantly lower than those in the control group(P<0.05).After treatment,the levels of forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),maximal voluntary ventilation(MVV)and FEV1/FVC of the observation group were significantly higher than those of the control group(P<0.05).Conclusion San′ao Decoction combined with azithromycin has significant clinical effect in the treatment of mycoplasma pneumonia in children,which can effectively shorten the course of disea
作者
邢楠
XING Nan(Shenyang Children′s Hospital,Shenyang 110033,Liaoning,Liaoning)
出处
《辽宁中医杂志》
CAS
2023年第5期126-129,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
辽宁省自然科学基金计划项目(20180550667)
沈阳市科技创新专项资金-国际科技合作专项(F14-232-6-04)
沈阳市重点实验室建设专项(F18-158-1-00)。
关键词
小儿支原体肺炎
三拗汤辨证加减
阿奇霉素
临床疗效
炎性因子
TH1/TH2细胞因子
肺功能
mycoplasma pneumonia in children
Modified San′ao Decoction(三拗汤辨证加减)according to syndrome differentiation
azithromycin
clinical effect
inflammatory factors
Th1/Th2 cytokines
lung function
