摘要
目的探讨三阴性乳腺癌(TNBC)患者中S1PR1、Caspase-3的表达及其与病理特征的关系。方法回顾性分析76例乳腺癌患者的病历资料,其中TNBC患者20例(TNBC组),非TNBC患者56例(非TNBC组)。采用免疫组化法检测两组乳腺癌标本中的S1PR1、Caspase-3表达,分析二者阳性表达与TNBC病理特征的关系。结果TNBC组标本中S1PR1、Caspase-3的阳性表达率高于非TNBC组(P<0.05)。不同淋巴结转移情况、TNM分期的TNBC患者的S1PR1、Caspase-3表达存在显著差异(P<0.05)。结论S1PR1、Caspase-3在TNBC患者中表达升高,且二者的表达与淋巴结转移情况、TNM分期具有密切联系。
Objective To explore the expressions of S1PR1 and Caspase-3 in patients with triple negative breast cancer(TNBC)and their relationships with pathological features.Methods The medical records of 76 patients with breast cancer were retrospectively analyzed,including 20 TNBC patients(TNBC group)and 56 non-TNBC patients(non-TNBC group).The expressions of S1PR1 and Caspase-3 in breast cancer specimens of the two groups were detected by immunohistochemistry,and the relationships between the positive expressions of the two indicators and the pathological features of TNBC were analyzed.Results The positive expression rates of SIPR1 and Caspase-3 in TNBC group were higher than those in non-TNBC group(P<0.05).There were significant differences in the expressions of SIPR1 and Caspase-3 in TNBC patients with different lymph node metastasis and TNM stage(P<0.05).Conclusions The expressions of S1PR1 and Caspase-3 increase in TNBC patients,and their expressions are closely related to lymph node metastasis and TNM stage.
作者
范学亮
王中山
王春锋
FAN Xueliang;WANG Zhongshan;WANG Chunfeng(Department of Pathology,Zhengzhou KingMed Clinical Laboratory Center,Zhengzhou 450016,China)
出处
《临床医学工程》
2023年第6期867-868,共2页
Clinical Medicine & Engineering