摘要
目的以“态靶辨治”理论为指导,通过治疗潮热中成药的用药特点及规律分析,为中成药的新药研发提供依据。方法构建所有治疗潮热的中成药数据库,通过Apriori关联规则分析、频数统计等统计学方法,分析其用药特点及量效规律。结果共筛选出30种中成药,中药为133味,药物总频次为298次。其中频次排名前五位的药物分别为熟地黄、茯苓、山药、麦冬、生地黄,最大剂量药物分别为茯苓18.53 g和熟地黄13.33 g。症状-症状的关联规则分析显示,二阶关联规则盗汗→潮热关联度最高,三阶关联规则咳嗽+盗汗→潮热关联度最高,四阶关联规则头晕+耳鸣+腰膝酸软→潮热关联度较高。药物-症状的关联规则分析显示,二阶关联规则生地黄→潮热的关联度最高,三阶关联规则天冬+麦冬→潮热的关联度最高,四阶关联规则天冬+生地黄+麦冬→潮热和天冬+麦冬+熟地黄→潮热的关联度最高。结论治疗潮热的中成药品种较为单一,主要针对肝肾阴虚引起的潮热。在未来的发展中应根据“态靶辨治”理论进一步探索潮热的发病特点,围绕“态靶同调”对中成药进行针对性新药研发。
Objective Under the guidance of the theory of"treatment based on the diff erentiation of state-target",to analyze the characteristics and dose-eff ect laws of traditional Chinese patent medicines in the treatment of hot flashes so as to provide a basis for the research and development of new traditional Chinese patent medicines.Methods A database of all the traditional Chinese patent medicines and simple preparations for the treatment of hot flashes was constructed,and their drug use characteristics and dose-effect laws were analyzed by the Apriori association rule analysis,frequency statistics and other statistical methods.Results A total of 30 traditional Chinese patent medicines were screened out,including 133 traditional Chinese herbs,and their total frequency was 298 times.The top fi ve drugs in terms of frequency ranking were prepared rehmannia root,Indian bread,common yam rhizome,dwarf lilyturf tuber and unprocessed rehmannia root.Meanwhile,the highest doses of drugs were 18.53 g of Indian bread and 13.33 g of prepared rehmannia root,respectively.The symptom-symptom association rule analysis showed that night sweating→tidal fever had the highest correlation in the second-order association rule,cough+night sweating→tidal fever had the highest correlation in the third-order association rule,while dizziness+tinnitus+sore and weak waist and knees→tidal fever had the highest correlation in the fourth-order association rule.The drug-symptom association rule analysis showed that unprocessed rehmannia root→tidal fever had the highest correlation in the second-order association rule,cochinchinese asparagus root+dwarf lilyturf tuber→tidal fever had the highest correlation in the third-order association rule,while cochinchinese asparagus root+unprocessed rehmannia root+dwarf lilyturf tuber→tidal fever and cochinchinese asparagus root+dwarf lilyturf tuber+prepared rehmannia root→tidal fever had the highest correlation in the fourth-order association rule.Conclusion The varieties of Chinese patent medicin
作者
张伟
张湘苑
卫若楠
赵林华
ZHANG Wei;ZHANG Xiangyuan;WEI Ruonan;ZHAO Linhua(College of Basic Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Institute of Metabolic Disease,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Beijing University of Chinese Medicine,Beijing 100029,China;Department of Cardioencephalopathy,Shiyan Hospital of Traditional Chinese Medicine,Shiyan 442000,China)
出处
《吉林中医药》
2023年第6期715-719,共5页
Jilin Journal of Chinese Medicine
基金
国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-D-202001)。
关键词
潮热
中成药
生地黄
态靶辨治
量效规律
hot flash
traditional Chinese patent medicines and simple preparations
unprocessed rehmannia root
treatment based on the diff erentiation of state-target
dose-eff ect laws
