摘要
目的 探讨直肠癌患者血清内皮唾液酸蛋白(TEM1)、信号素3A(Sema3A)水平与临床病理特征及预后的关系。方法 选取2018年2月至2019年2月于该院行直肠癌根治术的104例直肠癌患者作为研究组,以同期于该院体检的60例体检健康者为对照组。采用酶联免疫吸附试验检测血清TEM1、Sema3A水平,分析血清TEM1、Sema3A水平与直肠癌临床病理特征的关系,采用Kaplan-Meier生存曲线分析血清TEM1、Sema3A水平对直肠癌患者预后的影响,采用单因素及多因素Cox回归分析直肠癌患者预后的影响因素。结果 研究组血清TEM1、Sema3A水平明显高于对照组,差异有统计学意义(P<0.05);直肠癌患者术前血清TEM1、Sema3A水平与肿瘤分化程度、TNM分期及淋巴结转移有关(P<0.05);TEM1高表达患者的中位生存时间低于TEM1低表达患者,差异有统计学意义(P<0.05),Sema3A高表达患者的中位生存时间低于Sema3A低表达患者,差异有统计学意义(P<0.05);TNM分期Ⅲ期、肿瘤低分化、淋巴结转移、TEM1高表达、Sema3A高表达是影响直肠癌患者预后的独立危险因素(P<0.05)。结论 直肠癌患者血清TEM1、Sema3A水平升高,二者水平与TNM分期、肿瘤分化程度及淋巴结转移有关,是影响直肠癌患者预后的独立危险因素。
Objective To investigate the relationship between serum endothelial sialic acid protein(TEM1),semaphorin 3A(Sema3A)levels and clinicopathological features and prognosis in patients with rectal cancer.Methods Totally 104 patients with rectal cancer who underwent radical resection in the hospital from February 2018 to February 2019 were selected as the study group,and 60 healthy people who underwent physical examination in the hospital during the same period were selected as the control group.Serum TEM1 and Sema3A levels were detected by enzyme-linked immunosorbent assay.The relationship between serum TEM1,Sema3A levels and clinicopathological features of rectal cancer was analyzed.The effects of serum TEM1 and Sema3A levels on the prognosis of rectal cancer patients were analyzed by Kaplan-Meier survival curve.Univariate and multivariate Cox regression analysis were used to analyze the prognostic factors of rectal cancer patients.Results The levels of TEM1 and Sema3A in the study group were significantly higher than those in the control group(P<0.05).Preoperative serum TEM1 and Sema3A levels in patients with rectal cancer were related to tumor differentiation,TNM stage and lymph node metastasis(P<0.05).The median survival time of patients with high TEM1 expression was significantly shorter than that of patients with low TEM1 expression(P<0.05),and the median survival time of patients with high Sema3A expression was significantly shorter than that of patients with low Sema3A expression(P<0.05).TNM stageⅢ,low differentiation,lymph node metastasis,high expression of TEM1 and high expression of Sema3A were independent risk factors for the prognosis of rectal cancer patients(P<0.05).Conclusion The serum levels of TEM1 and Sema3A are increased in patients with rectal cancer,which are associated with TNM stage,tumor differentiation and lymph node metastasis.High TEM1 and Sema3A levels are independent risk factors for the prognosis of patients with rectal cancer.
作者
岳峰
江旗琳
陈淼
徐媛媛
YUE Feng;JIANG Qilin;CHEN Miao;XU Yuanyuan(Department of Gastrointestinal Surgery,Handan City Central Hospital,Handan,Hebei 056001,China)
出处
《国际检验医学杂志》
CAS
2023年第12期1484-1489,共6页
International Journal of Laboratory Medicine
基金
河北省医学科学研究课题计划项目(20202465)。
关键词
直肠癌
内皮唾液酸蛋白
信号素3A
预后
危险因素
rectal cancer
endothelial sialic acid protein
semaphorin 3A
prognosis
risk factors
