摘要
【目的】探讨不同时机应用促红细胞生成素(EPO)治疗早产儿贫血的效果及对血常规指标的影响。【方法】选择2020年7月至2022年7月两院收治的90例贫血早产儿,根据治疗时间的不同将其分为观察组、对照组,每组45例。观察组出生第2周后给予EPO治疗,对照组出生第3周给予EPO治疗,两组均治疗至出生第5周。检测两组治疗前后贫血指标[血红蛋白(Hb)、血细胞比容(HCT)、网织红细胞计数(Ret)]水平,检测两组治疗前后血常规指标[红细胞计数(RBC)、平均红细胞血红蛋白含量(MCHC)、血小板(BPC)]水平,检测两组治疗前后造血物质[叶酸、维生素B 12、铁蛋白(SF)]水平,记录并比较两组治疗期间输血人数,计算输血率,比较两组不良反应发生情况。【结果】治疗后,观察组Hb、HCT水平较治疗前无明显变化(P>0.05),观察组Ret水平高于治疗前(P<0.05),对照组Hb、HCT、Ret水平低于治疗前(P<0.05),且观察组Hb、HCT、Ret水平高于对照组(P<0.05)。治疗后,观察组RBC水平较治疗前无明显变化(P>0.05),观察组MCHC水平及对照组RBC、MCHC水平较治疗前显著降低,观察组与对照组BPC水平较治疗前显著上升(P<0.05),且观察组RBC水平显著高于对照组(P<0.05),观察组与对照组MCHC、BPC水平比较,差异无统计学意义(P>0.05)。治疗后,观察组叶酸、维生素B 12、SF水平及对照组叶酸、维生素B 12水平与治疗前比较,差异无统计学意义(P>0.05),对照组SF水平低于治疗前(P<0.05),且观察组SF水平高于对照组(P<0.05)。两组输血率比较,差异无统计学意义(P=0.398)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】出生第2周时应用EPO治疗早产儿贫血虽不能显著降低输血率,但可有效改善患儿贫血状况,且安全性较高。
【Objective】To explore the effect of using erythropoietin(EPO)at different time points in the treatment of anemia in premature infants and its impact on blood routine indicators.【Methods】A total of 90 premature infants with anemia admitted to two hospitals from July 2020 to July 2022 were selected and divided into an observation group and a control group based on different treatment times,with 45 cases in each group.The observation group received EPO treatment after the second week of birth,while the control group received EPO treatment after the third week of birth.Both groups were treated until the fifth week of birth.The levels of anemia indexes[hemoglobin(Hb),hematocrit(HCT),reticulocyte count(Ret)]in the two groups were measured before and after treatment.The levels of blood routine indicators(RBC,MCHC and BPC)were measured before and after treatment in both groups.Before and after treatment,the levels of hematopoietic substances[folic acid,vitamin B 12 and ferritin(SF)]in two groups were tested,and the number of blood transfusions during the treatment period was recorded and compared.The blood transfusion rate was calculated,and the occurrence of adverse reactions in the two groups was observed and compared.【Results】After treatment,there was no significant change in Hb and HCT levels in the observation group compared to before treatment(P>0.05),while Ret levels in the observation group were higher than before treatment(P<0.05).The Hb,HCT,Ret levels in the control group were lower than before treatment(P<0.05),and the Hb,HCT,Ret levels in the observation group were higher than those in the control group(P<0.05).After treatment,there was no significant change in the RBC level in the observation group compared to before treatment(P>0.05).The MCHC level in the observation group and the RBC and MCHC levels in the control group decreased significantly compared to before treatment.The BPC level in the observation group and the control group increased significantly compared to before treatment(P<0.05),an
作者
张磊
贾阳
安婷婷
苏芬玲
习颖
ZHANG Lei;JIA Yang;AN Ting-ting(Department of Neonatology,Xi'an Daxing Hospital,Xi'an Shaanxi 710000)
出处
《医学临床研究》
CAS
2023年第5期668-671,共4页
Journal of Clinical Research
基金
陕西省重点研发计划项目(编号:2019SF-137)。
