摘要
背景:近年来有研究显示,肥胖与慢性炎症密切相关,由于能量摄入过量使内脏脂肪组织发生炎性巨噬细胞浸润和炎症反应,对于脂肪组织纤维化的调节至关重要。目的:总结炎症相关信号参与调控脂肪组织纤维化的相关分子机制,通过抗炎途径为治疗脂肪组织纤维化和相关代谢性疾病提供参考依据。方法:检索中国知网、PubMed数据库相关文献,中文检索词为“炎症、炎症因子、炎症信号、脂肪纤维化、脂肪组织纤维化”;英文检索词为“inflammation,inflammatory factors,inflammatory signal,lip fibrosis,adipose fibrosis,adipose tissue fibrosis”,检索时限为2003年1月至2022年12月,最终纳入符合标准的52篇文献进行综述。结果与结论:①在肥胖期间,内脏脂肪组织通过脂肪细胞增生和肥大进行扩张以储存多余的能量,发生重塑或功能改变后引起的缺陷主要包括血管新生受损、白色脂肪组织缺氧促进脂肪细胞凋亡、巨噬细胞浸润以及脂肪组织纤维化,脂肪组织纤维化对于脂肪细胞的自然生长具有不利影响;②触发脂肪组织慢性炎症的因素包括多种信号刺激,如缺氧导致的脂肪细胞死亡、细胞外基质重塑引起的机械信号转导以及脂肪源性因子失调;③脂肪细胞分泌的白细胞介素1β、肿瘤坏死因子α、C型凝集素和脂联素炎症因子以及NF-κB、TGF-β/Smad、MAPK等炎症相关的信号通路共同调控脂肪组织纤维化进程。
BACKGROUND:In recent years,studies have shown that obesity is closely related to chronic inflammation.Due to excessive energy intake,inflammatory macrophage infiltration and inflammatory response occur in visceral adipose tissue,which is crucial for the regulation of adipose tissue fibrosis.OBJECTIVE:To summarize the molecular mechanism of inflammation-related signals involved in the regulation of adipose tissue fibrosis and to provide reference for the treatment of adipose tissue fibrosis and related metabolic diseases through anti-inflammatory pathways.METHODS:Relevant documents were retrieved from CNKI and PubMed,and the Chinese and English search words were“inflammation,inflammatory factors,inflammatory signals,lip fibrosis,adipose fibrosis,adipose tissue fibrosis”respectively.The search period was from January 2003 to December 2022.Finally,52 documents meeting the criteria were included for review.RESULTS AND CONCLUSION:During obesity,visceral adipose tissue expands through adipocyte proliferation and hypertrophy to store excess energy,and defects caused by remodeling or functional changes mainly include impaired angiogenesis,adipocyte apoptosis promoted by white adipose tissue hypoxia,macrophage infiltration,and adipocyte fibrosis.Adipose tissue fibrosis has adverse effects on the natural growth of adipose cells.The factors that trigger chronic inflammation of adipose tissue include a variety of signal stimuli,such as adipocyte death caused by hypoxia,mechanical signal transduction caused by extracellular matrix remodeling and lipogenic factor imbalance.Inflammatory factors such as interleukin-1β,tumor necrosis factor-α,C-type lectins and adiponectin secreted by adipocytes and other inflammatory signaling pathways such as nuclear factor-κB,transforming growth factor-β/Smad and MAPK jointly regulate the process of adipose tissue fibrosis.
作者
王伟庆
周越
Wang Weiqing;Zhou Yue(School of Sports and Human Sciences,Beijing Sport University,Beijing 100084,China)
出处
《中国组织工程研究》
CAS
北大核心
2024年第8期1307-1312,共6页
Chinese Journal of Tissue Engineering Research
关键词
炎症
脂肪组织纤维化
巨噬细胞
脂肪
肥胖
炎症因子
能量
抗炎
inflammation
adipose tissue fibrosis
macrophage
fat
obesity
inflammatory factor
energy
anti-inflammation
