摘要
神经系统疾病是世界人口残疾及死亡的重要原因,主要包括阿尔茨海默病、帕金森病、肌萎缩侧索硬化症、多发性硬化及偏头痛。有大量研究表明神经系统疾病的发生与γ-氨基丁酸(gamma-aminobutynic acid, GABA)能系统的紊乱密切相关。氢质子磁共振波谱是一种无创检测活体组织代谢产物的影像学技术,新兴的Meshcher-Garwood点分辨光谱(Meshcher-Garwood point resolved spectroscopy, MEGA-PRESS)序列采用了J差分谱编辑技术实现了对脑内GABA水平的定量,为临床医生对疾病的诊断、治疗及预后管理提供更充实的影像学数据。本文对MEGA-PRESS序列原理及其在神经系统常见疾病中的GABA定量研究进行综述,旨在评价该技术的GABA定量分析对神经系统疾病早期检测、诊断的临床意义。
Neurological diseases are the important cause of disability and death worldwide,mainly including Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,multiple sclerosis and migraine.Numerous studies have demonstrated the occurrence of neurological diseases is closely related to the disruption of the gamma-aminobutynic acid(GABA)system.Proton magnetic resonance spectroscopy is an imaging technique for the non-invasive detection of metabolites in vivo,the emerging Meshcher-Garwood point resolved spectroscopy(MEGA-PRESS)sequence achieves quantification of GABA levels in the brain using J-difference spectrum editing technology,providing clinicians with enriched imaging data for the diagnosis,treatment and prognostic management of diseases.This paper reviewed the principle of the MEGA-PRESS sequence and its research on GABA quantification in neurological diseases,in order to evaluate the clinical significance of GABA quantification in early detection and diagnosis of neurological diseases with this technique.
作者
符晓娜
汪晶
FU Xiaona;WANG Jing(Department of Radiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Hubei Province Key Laboratory of Molecular Imaging,Wuhan 430030,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2023年第6期89-93,共5页
Chinese Journal of Magnetic Resonance Imaging
基金
湖北省自然科学基金面上项目(编号:2021CFB447)。
