摘要
治疗脱髓鞘疾病的重点是保护髓鞘的完整性和促进髓鞘修复,这离不开有效的成像工具及其显像剂将疾病进展与髓鞘形成的程度联系起来。近年来,髓鞘特异性探针的开发使得活体内直接定量监测髓鞘含量成为可能,各种髓鞘的成像技术日益成熟极大地提高了监测髓鞘的特异性和敏感性。运用不同髓鞘探针和影像手段的优势互补能为以后临床脱髓鞘疾病的检测和治疗提供更多的选择手段。笔者对应用于光学成像、核医学成像、磁共振成像和多模态成像等影像学技术的髓鞘探针在脱髓鞘疾病的研究进展进行综述。
The treatment of demyelinating diseases focuses on protecting myelin integrity and promoting myelin repair, and these efforts are inseparable from effective imaging tools and agents that link disease progression to the degree of myelin formation. In recent years,the development of myelin-specific probes has made it possible to directly and quantitatively monitor myelin content in vivo. The imaging technology of various marrow sheaths has become increasingly mature and greatly improved the specificity and sensitivity of monitoring myelin sheath. The complementary advantages of different myelin probes and imaging methods can provide more options for the detection and treatment of clinical demyelinating diseases in the future. This article reviews the progress of myelin probes used in optical imaging, nuclear medicine imaging, magnetic resonance imaging, and multimodal imaging in demyelinating diseases.
作者
李国栋
翁娜
李祥林
刘岩
王旭
LI Guodong;WENG Na;LI Xianglin;LIU Yan;WANG Xu(Department of Nuclear Medicine,Binzhou Medical University Hospital,Binzhou 256600,China;School of Medical Imaging,Binzhou Medical University,Yantai 264100,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2022年第8期135-138,共4页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金(编号:81771828)
国家自然科学基金青年科学基金(编号:11805247)。
关键词
髓鞘探针
脱髓鞘
多发性硬化症
荧光成像
正电子发射断层显像
磁共振成像
myelin probes
demyelination
multiple sclerosis
fluorescence imaging
positron emission tomography
magnetic resonance imaging
