摘要
长链非编码RNA(lncRNA)是一类长度大于200个核苷酸且无蛋白质编码能力的RNA,但在增殖、凋亡、迁移、侵袭和分化等多种生物过程中起着非常重要的调节作用。研究发现lncRNA与心肌缺血再灌注(I/R)损伤的发生发展密切相关。本综述讨论了lncRNA减少心肌I/R损伤及其可能机制的研究进展。
Long non-coding RNA(lncRNA)is a class of RNA more than 200 nucleotides long and has no protein-coding capacity,but it plays a very important role in regulating various biological processes such as proliferation,apoptosis,migration,invasion and differentiation.It has found that lncRNA is closely related to the development of myocardial ischemia/reperfusion(I/R)injury.This review discusses the advances in the reduction of myocardial I/R injury and its possible mechanisms by lncRNA.
作者
成姣
谢佳欣
刘晨
黄骥
韦星
CHENG Jiao;XIE Jiaxin;LIU Chen;HUANG Ji;WEI Xing(Institute of Cardiovascular Diseases,University of South China&Key Laboratory for Arteriosclerology of Hunan Province&International Scientific and Technological Innovation Cooperation Base for Arteriosclerotic Diseases in Hunan Province,Hengyang,Hunan 421001,China)
出处
《中国动脉硬化杂志》
CAS
2023年第6期539-545,共7页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(82100789)
湖南省教育厅科学研究重点项目(19A432)。
关键词
长链非编码RNA
心肌缺血再灌注损伤
氧化应激
自噬
炎症反应
细胞凋亡
long non-coding RNA
myocardial ischemia/reperfusion injury
oxidative stress
autophagy
inflammatory response
apoptosis
