摘要
心血管病仍是全球发病率及致死率最高的疾病之一。HOX转录反义RNA(HOTAIR)是具有反式转录调控作用的长链非编码RNA,其表达或功能异常与人类疾病的发生发展关系密切。越来越多的研究表明,HOTAIR可能参与调节心血管病的发生发展,有潜力成为心血管病诊断的生物标记物以及治疗靶标。文章就长链非编码RNA HOTAIR在心血管病中的研究进展进行综述。
Cardiovascular diseases remain to be one of the diseases with the highest morbidity and mortality in the world.HOX transcript antisense RNA(HOTAIR)is a long chain non-coding RNA with trans-transcriptional regulation,whose expression and function are closely associated with the occurrence and development of human diseases.A growing body of research has demonstrated the important role of HOTAIR in the regulation of the occurrence and development of cardiovascular diseases.HOTAIR may present a promising option as a new biomarker and therapeutic target of cardiovascular diseases.In the current paper,we reviewed the research progress of HOTAIR in cardiovascular diseases.
作者
刘正兵(综述)
丁世芳(审校)
LIU Zheng-bing;DING Shi-fang(Department of Cardiovascular Medicine,Jinling Hospital,Nanjing School Clinical Medicine,Southern Medical University/General Hospital of Eastern Theater Command,PLA,Nanjing 210002,Jiangsu,China;Department of Cardiology,General Hospital of Central Theater Command of PLA,Wuhan 430070,China)
出处
《医学研究生学报》
CAS
北大核心
2021年第5期530-533,共4页
Journal of Medical Postgraduates
基金
全军后勤科研计划项目(AWS13C008)。
