摘要
含氟药物在临床药物中占据重要地位。在药物分子中引入氟原子可显著改变药效活性,是药物结构修饰的重要策略之一。光化学合成作为一种温和、绿色、高效的合成手段,近年来受到了广泛的关注。特别是光诱导的氟化策略,在氟化产物的合成中呈现出巨大的优势和潜力。本文着重对光催化氟化反应进行总结,旨在为更多含氟药物的合成提供参考。
Fluorine-containing drugs occupy an important position in clinical drugs.The introduction of fluorine atoms into drug molecules can significantly change the pharmacodynamic activity,which is one of the important strategies for drug structural modification.As a mild,green and efficient synthesis method,photochemical synthesis has received extensive attention in recent years.In particular,the photo-induced fluorination strategy shows great advantages and potential in the synthesis of fluorinated products.This article focuses on the photocatalytic fluorination reaction,aiming to provide reference for the synthesis of more fluorine-containing drugs.
作者
孙艳
许宁
SUN Yan;XU Ning(Zhejiang Evaluation Center for Medical Service and Administration,Hangzhou,Zhejiang 310003,China;College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China)
出处
《浙江化工》
CAS
2023年第5期1-5,共5页
Zhejiang Chemical Industry
关键词
光催化
氟化
中间体
含氟药物
碳氢活化
photocatalysis
fluorination
Intermediates
fluoride-containing drugs
hydrocarbon activation
